Is Serotonin safe in cosmetics?
Serotonin has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: prohibited.
Moderate
Cosmetic Ingredient
Serotonin
Also known as: 5-22-12-00016, 3-(beta-Aminoethyl)-5-hydroxyindole, BRN 0143524, EINECS 200-058-9, Hippophain (+13 more)
INCI: SEROTONIN
Serotonin (CAS 50-67-9) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 50-67-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Serotonin is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H361).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin Conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-(2-aminoethyl)-1H-indol-5-ol
InChIKey
QZAYGJVTTNCVMB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
prohibited
US Notes
Not specifically listed as a prohibited cosmetic ingredient by FDA; however, its pharmacological activity as a neurotransmitter creates a potential drug-cosmetic boundary issue.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Serotonin.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Serotonin.
Known Synonyms
5-22-12-00016
3-(beta-Aminoethyl)-5-hydroxyindole
BRN 0143524
EINECS 200-058-9
Hippophain
5-Hydroxy-3-(beta-aminoethyl)indole
Substanz DS
UNII-333DO1RDJY
3-(2-azanylethyl)-1H-indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
5-Hydroxytriptamine
5-hydroxy-tryptamine
Antemoqua
Hippophaine
serotonine
Regulatory Lists
active_ingredient; animal_products; Europe; pharmaceutical; residue
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SEROTONIN
ChEMBL ID
CHEMBL39
Max Phase
3
Adverse Event Associations
1
Frequently Asked Questions
Is Serotonin allowed in the EU?
Serotonin EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Serotonin do in cosmetics?
Serotonin functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 50-67-9.
Is Serotonin used outside cosmetics?
Serotonin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Serotonin have different safety status in cosmetics vs industrial chemicals?
Serotonin is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H361).
Compliance Tools
Check Serotonin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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