Is Rose Ketone-4 safe in cosmetics?
Rose Ketone-4 has a safety rating of "MODERATE" in our database. EU status: restricted. US status: restricted.
Rose Ketone-4
Also known as: 2-Buten-1-one, 1-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-, beta-Damascenone, EINECS 245-833-2, FEMA No. 3420, UNII-U66V25TBO0
INCI: ROSE KETONE-4
Rose Ketone-4 (CAS 23696-85-7) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: restricted, max 0.02%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 23696-85-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(E)-1-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)but-2-en-1-one
InChIKey
POIARNZEYGURDG-FNORWQNLSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.02%
US US Status
restricted
US Notes
Permitted in fragrances; IFRA restricted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Rose Ketone-4.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Rose Ketone-4 based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted
Source: EU 2023/1545; SCCS
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
88.74%
DPRA Lys %
3.44%
KeratinoSens IC50
53 µM
hCLAT CV75
12.317 µg/mL
NESIL
100 µg/cm²
GHS: 1B
Human: positive
Source: DPRA: Unilever commissioned, Charles River | Unilever commissioned, IIVS; KS: Unilever commissioned, Charles River; hCLAT: Unilever commissioned, IIVS; HPPT: [448] RIFM (1978): RIFM report number 15395, July 12, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 100 | - | - |
| HRIPT | - | 0 | - | - | - |
| HRIPT | - | 0 | - | - | - |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Oral products (b) Other products. Max: (b) 0.02%.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 0.02%
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "patch_test_frequency_pct": "0.2", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "source": "EU 2023/1545; SCCS"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (1)
JECFA Evaluation
4-(2,6,6-TRIMETHYLCYCLOHEXA-1,3-DIENYL)BUT-2-EN-4-ONE | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/96 | FAS 42-JECFA 51/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Rose Ketone-4.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
eu_cosing_listed
Known Synonyms
2-Buten-1-one, 1-(2,6,6-trimethyl-1,3-cyclohexadien-1-yl)-
beta-Damascenone
EINECS 245-833-2
FEMA No. 3420
UNII-U66V25TBO0
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
inert_ingredient; non_food_use; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Rose Ketone-4 allowed in the EU?
Rose Ketone-4 EU regulatory status: restricted. Maximum allowed concentration: 0.02%. This is based on EU Regulation 1223/2009 and its amendments.
What does Rose Ketone-4 do in cosmetics?
Rose Ketone-4 functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 23696-85-7.
Is Rose Ketone-4 used outside cosmetics?
Rose Ketone-4 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Rose Ketone-4 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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