Is Retinyl Retinoate safe in cosmetics?
Retinyl Retinoate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Retinyl Retinoate
Also known as: UNII-5AT5X9J439, Retinoic acid, ester with retinol, Retinoic acid, retin-15-yl ester, EP-reti plus
INCI: RETINYL RETINOATE
Retinyl Retinoate (CAS 15498-86-9) is a cosmetic active ingredient functioning as Hybrid vitamin A derivative combining retinol and retinoic acid moieties in a. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 15498-86-9 →
Auto-generated CPSR Part A draft with source citations
Function
Hybrid vitamin A derivative combining retinol and retinoic acid moieties in a single ester; promotes wrinkle reduction and skin renewal
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restriction; marketed as a cosmetic active
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Retinyl Retinoate.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Retinyl Retinoate, relevant to systemic exposure and MoS calculations.
Absorption %
2-5%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum/epidermis
Molecular Weight
568.9 Da
Log P
14.2
Systemic Absorption
minimal
Topical Bioavailability
1-3%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation
Source: J Cosmet Dermatol 2017
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "15498-86-3", "anti_acne_mechanism": "keratolytic/comedolytic/anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory/non_inflammatory", "sebum_reduction_pct_clinical": "8-12", "keratolytic_strength": "moderate", "exfoliation_mechanism": "chemical", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct…
anti_aging
{"anti_aging_claim": "anti-wrinkle, collagen-boosting, brightening", "mechanism_of_action": "Hybrid retinoid ester, dual retinoic acid release, gentle conversion", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Yes", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "12-22", "clinical_study_duration_weeks": "12", "sample_size": "40", "double_blind": "Yes", "placebo_con…
cost_pricing
{"cost_tier": "luxury", "estimated_cost_per_kg_usd_low": "1500", "estimated_cost_per_kg_usd_high": "2800", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "Global (synthetic)", "bulk_discount_threshold_kg": "0.5", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "R…
depigmentation
{"cas_number": "15498-86-5", "ingredient_class": "combined_mechanism", "primary_mechanism_of_action": "Synthetic or isolated bioactive with melanin reduction properties", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical":…
dermal_absorption
{"molecular_weight_da": "568.9", "log_p_value": "14.2", "skin_penetration_level": "stratum-corneum", "penetration_depth": "stratum corneum/epidermis", "absorption_pct": "2-5", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "weakens", "bioavailability_topical_pct": "1-3", "safety_margin_factor": "low", "so…
pregnancy_detail
{"pregnancy_safe": "no", "breastfeeding_safe": "no", "trimester_restriction": "all", "risk_category": "not-rated", "reason": "Dual retinoid derivative", "alternative_ingredient": "Bakuchiol", "source": "dermatology literature"}
solubility_hlb
{"water_soluble": "no", "oil_soluble": "yes", "soluble_in": "oils, ethanol", "insoluble_in": "water, glycerin, propylene glycol", "log_p": "15.8", "appearance": "yellow powder", "source": "Grant Industries"}
synergy
{"inci_name_2": "Squalane + Vitamin E", "synergy_type": "stability-enhancement", "synergy_description": "Ester retinoid with stabilizing oils for enhanced stability and delivery", "combined_benefit": "Improved retinoid stability, enhanced penetration, reduced irritation, effective anti-aging", "efficacy_multiplier": "2.3x", "mechanism_of_action": "Retinyl retinoate is stable ester; squalane enhanc…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Retinyl Retinoate.
Regulatory Flags
retinoid
hybrid-molecule
next-generation
not-eu-restricted
small-rct-only
promising
Known Synonyms
UNII-5AT5X9J439
Retinoic acid, ester with retinol
Retinoic acid, retin-15-yl ester
EP-reti plus
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
RETINYLRETINOATE
ChEMBL ID
CHEMBL451039
Frequently Asked Questions
Is Retinyl Retinoate allowed in the EU?
Retinyl Retinoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Retinyl Retinoate do in cosmetics?
Retinyl Retinoate functions as: Hybrid vitamin A derivative combining retinol and retinoic acid moieties in a single ester; promotes wrinkle reduction and skin renewal. It is classified as a Active Ingredient in our database. CAS number: 15498-86-9.
Is Retinyl Retinoate used outside cosmetics?
Retinyl Retinoate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Retinyl Retinoate compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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