Is Retinyl Acetate safe in cosmetics?
Retinyl Acetate has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
Retinyl Acetate
INCI: RETINYL ACETATE
Retinyl Acetate (CAS 127-47-9 [^1_7]) is a cosmetic cosmetic ingredient functioning as Skin conditioning; antioxidant (Vitamin A ester, converts to retinol in skin). EU Regulation 1223/2009 status: restricted, max 0.05%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 127-47-9 [^1_7] →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning; antioxidant (Vitamin A ester, converts to retinol in skin) [^1_8]
Safety Rating
GOOD
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.05%
US US Status
permitted
US Notes
Permitted cosmetic ingredient; no concentration limits; also GRAS for food use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Retinyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
8 property records from structured ingredient metadata.
acne
{"cas_number": "127-47-9", "anti_acne_mechanism": "keratolytic/comedolytic", "comedogenicity_rating_0_to_5": "2", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restri…
anti_aging
{"anti_aging_claim": "anti-wrinkle, hydration-plumping", "mechanism_of_action": "Ester converted to retinol, gentle approach", "target_skin_layer": "epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "5-12", "clinical_study_duration_weeks": "16", "sample_size": "50", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD", "im…
anti_pollution
{"cas_number": "127-47-9", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibitio…
pregnancy_detail
{"pregnancy_safe": "no", "breastfeeding_safe": "no", "trimester_restriction": "all", "risk_category": "not-rated", "reason": "Vitamin A derivative", "alternative_ingredient": "Bakuchiol", "source": "dermatology literature"}
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "acceptable", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "caution", "hyperpigmentation": "acceptable", "aging_mature": "acceptable", "dehydrated": "acceptable", "skin_benefit_primary": "anti-aging", "skin_benefit_secondary": "skin-renewal", "mec…
stability
{"shelf_life_months": "24", "shelf_life_opened_months": "12", "storage_temp_min_c": "2", "storage_temp_max_c": "25", "light_sensitive": "yes", "air_sensitive": "yes", "moisture_sensitive": "moderate", "oxidation_prone": "yes", "requires_nitrogen_blanket": "no", "stability_indicator": "moderate", "degradation_products": "retinol, acetic acid", "recommended_packaging": "amber glass, tube", "antioxid…
uv_stability
{"uv_stable": "no", "uv_degradation_rate": "fast", "photosensitizer": "yes", "phototoxic": "yes", "photoallergic": "no", "requires_uv_protection_packaging": "yes", "color_change_uv": "yes", "odor_change_uv": "yes", "efficacy_loss_uv_pct": "75-85", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under…
vitamin
{"cas_number": "127-47-9", "ingredient_class": "vitamin_A", "chemical_form": "ester", "derivative_type": "pro_vitamin", "molecular_weight_Da": "328.49", "water_solubility": "insoluble", "oil_solubility": "soluble", "log_P": "7.60", "stability_to_light": "moderate", "stability_to_heat": "good", "stability_to_oxidation": "moderate", "stability_to_pH_acid": "excellent", "stability_to_pH_alkaline": "g…
Expert Verdict
Expert safety assessment and concern-level summary for Retinyl Acetate.
Frequently Asked Questions
Is Retinyl Acetate allowed in the EU?
Retinyl Acetate EU regulatory status: restricted. Maximum allowed concentration: 0.05%. This is based on EU Regulation 1223/2009 and its amendments.
What does Retinyl Acetate do in cosmetics?
Retinyl Acetate functions as: Skin conditioning; antioxidant (Vitamin A ester, converts to retinol in skin) [^1_8]. It is classified as a cosmetic ingredient in our database. CAS number: 127-47-9 [^1_7].
Compliance Tools
Check Retinyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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