Is Retinoic Acid (Tretinoin) Regulatory safe in cosmetics?
Retinoic Acid (Tretinoin) Regulatory has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted.
Good
Antioxidant
Retinoic Acid (Tretinoin) Regulatory
Also known as: ATRA, Tretinoin, all-trans-Vitamin A acid, Atragen, Aberel (+15 more)
INCI: RETINOIC ACID
Retinoic Acid (Tretinoin) Regulatory (CAS 302-79-4) is a cosmetic antioxidant functioning as biological rate limiter. EU Regulation 1223/2009 status: permitted, max 0.05%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 302-79-4 →
Auto-generated CPSR Part A draft with source citations
Function
biological rate limiter
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.05%
US US Status
restricted
US Notes
Cosmetic Use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Retinoic Acid (Tretinoin) Regulatory.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOEC | =0.04 mg/L | Rat | environmental | short-term | ECOTOX |
| NOEC | =0.5 mg/L | Rat | environmental | short-term | ECOTOX |
| NOEC | =1.2 mg/L | Rat | environmental | short-term | ECOTOX |
| NOEC | =0.13 mg/L | Rat | environmental | short-term | ECOTOX |
| NOEC | =0.8 mg/L | Rat | environmental | short-term | ECOTOX |
| NOEC | =0.03 mg/L | Rat | environmental | short-term | ECOTOX |
| NOEC | =0.035 mg/L | Rat | environmental | short-term | ECOTOX |
| LOEL | =20 mg/kg-day | Mouse | oral | short-term | ECOTOX |
| LOEL | =30 mg/kg-day | Mouse | oral | short-term | ECOTOX |
| LOEL | =20 mg/kg-day | Mouse | oral | short-term | ECOTOX |
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 375
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 375
BRIN Brazil/India Cosmetics
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (10)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | banned | - | - |
| IN | banned | - | all cosmetics — classified as drug in India |
| IN | drug_classification | - | skin care products with retinoid effects |
| AU | restricted | - | prescription only |
| GCC | banned | - | All cosmetics |
| BR | banned | - | - |
| CA | banned | - | - |
| CA | restricted | 0% — prohibited as cosmetic ingredient | All cosmetics (drug only) |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Regulatory List Membership (3)
California Proposition 65 (OEHHA)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Retinoic Acid (Tretinoin) Regulatory.
Regulatory Flags
prop65
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
ATRA
Tretinoin
all-trans-Vitamin A acid
Atragen
Aberel
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
Retinoic acid, all-trans-
all-trans-Retinoic acid
Acid A Vit (Belgium, Netherlands)
Aknefug
Alltrans-retinoic acid
all-trans-Vitamin A1 acid
15-Apo-beta-caroten-15-oic acid
BRN 2057223
3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-all-trans-tetraenoic acid
Effederm
EINECS 206-129-0
NSC-122758
beta-RA
Retin-A
Chemical Function
No specific technical function
Regulatory Lists
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
Personal care; Southeast Asia
pharmaceutical
pharmaceutical
pharmaceutical
pharmaceutical
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
banned; Europe; Personal care
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TRETINOIN
ChEMBL ID
CHEMBL38
Max Phase
4
Adverse Event Associations
2774
Frequently Asked Questions
Is Retinoic Acid (Tretinoin) Regulatory allowed in the EU?
Retinoic Acid (Tretinoin) Regulatory EU regulatory status: permitted. Maximum allowed concentration: 0.05%. This is based on EU Regulation 1223/2009 and its amendments.
What does Retinoic Acid (Tretinoin) Regulatory do in cosmetics?
Retinoic Acid (Tretinoin) Regulatory functions as: biological rate limiter. It is classified as a Antioxidant in our database. CAS number: 302-79-4.
Is Retinoic Acid (Tretinoin) Regulatory used outside cosmetics?
Retinoic Acid (Tretinoin) Regulatory also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Retinoic Acid (Tretinoin) Regulatory compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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