NOAEL Data Prop 65 Cosmetic Ingredient

All-trans-Retinoic acid

Also known as: ATRA, Tretinoin, all-trans-Vitamin A acid, Atragen, Aberel (+14 more)

CAS 302-79-4

All-trans-Retinoic acid (CAS 302-79-4) is a chemical substance; key hazard signal: developmental. Key regulatory status: California Proposition 65, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, CA Prop 65.

View cosmetic safety profile for Tretinoin →

SOURCE noael studies public
NOAEL studies
27
SOURCE chemical inventory jurisdictions
Regulatory lists
12
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields
Name
All-trans-Retinoic acid
CAS Number
302-79-4
DTXSID
DTXSID7021239
Molecular Formula
C20H28O2
InChI Key
SHGAZHPCJJPHSC-YCNIQYBTSA-N
Monoisotopic Mass
300.20893
Synonyms
ATRATretinoinall-trans-Vitamin A acidAtragenAberel(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acidRetinoic acid, all-trans-Acid A Vit (Belgium, Netherlands)AknefugAlltrans-retinoic acidall-trans-Vitamin A1 acid15-Apo-beta-caroten-15-oic acid

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records
ChemicalToxicity TypeCancerDevelopmentalListed
-developmentalNoYes-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 1 records
No specific technical function

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 12 records
ListKeywordSource
OEHHA Proposition 65 (3/2019)STATE OF CALIFORNIA ENVIRONMENTAL PROTECTION AGENCYOEHHA Proposition 65 List
OEHHA Proposition 65 (1/2023)California Office of Environmental Health Hazard AssessmentOEHHA Proposition 65 List
Personal care; Southeast AsiaAseanASEAN Cosmetics
pharmaceuticalUS International Trade CommissionCPCat
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
pharmaceuticalFDAUnited States Food and Drug Administration (FDA)
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
Canada; pharmaceuticalDrugBankDrugBank
banned; Europe; Personal careEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 27 of 27 studies
ValueUnitEndpointRouteSpeciesSource
SQEdevelopmentallisting typeCalifornia Proposition 65 listing--California Proposition 65
SQEdevelopmentallisting typeCalifornia Proposition 65 listing--California Proposition 65
SQEdevelopmentallisting typeCalifornia Proposition 65 listing--California Proposition 65
6.9uL/min/10^6 cellsClint-RatNTP_ICE_adme_parameters
10.5uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
5688UTC01RUNIIFDA UNII substance identifier--openFDA substances
5688UTC01RUNIIFDA UNII substance identifier--openFDA substances
5688UTC01RUNIIFDA UNII substance identifier--openFDA substances
5688UTC01RUNIIFDA UNII substance identifier--openFDA substances
-fractionFu-RatNTP_ICE_adme_parameters
0.00597fractionFu-HumanNTP_ICE_adme_parameters
=2000mg/kg bwLD50oralRatNTP_ICE_acute_oral
=20mg/kg bw/dayLOELoralMouseToxValDB_ECOTOX
=30mg/kg bw/dayLOELoralMouseToxValDB_ECOTOX
=100mg/kg bw/dayLOELdermalRatToxValDB_ECOTOX
-unitlessModel Score--NTP_ICE_endocrine
=0.03mg/LNOECenvironmentalRatToxValDB_ECOTOX
=0.035mg/LNOECenvironmentalRatToxValDB_ECOTOX
=0.04mg/LNOECenvironmentalRatToxValDB_ECOTOX
=0.13mg/LNOECenvironmentalRatToxValDB_ECOTOX
=0.5mg/LNOECenvironmentalRatToxValDB_ECOTOX
=0.8mg/LNOECenvironmentalRatToxValDB_ECOTOX
=1.2mg/LNOECenvironmentalRatToxValDB_ECOTOX
=20mg/kg bw/dayNOELoralMouseToxValDB_ECOTOX
=25mg/kg bw/dayNOELdermalRatToxValDB_ECOTOX
=30mg/kg bw/dayNOELoralMouseToxValDB_ECOTOX
=250mg/kg bw/dayNOELdermalRatToxValDB_ECOTOX

Showing 27 of 27 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
active
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL TRETINOIN
ChEMBL Phase
4
Adverse Events
2774
Bioactivity
38
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for All-trans-Retinoic acid?

All-trans-Retinoic acid has 27 NOAEL studies in the database. The lowest reported value is developmental listing type. Source: California Proposition 65.

What regulatory lists include All-trans-Retinoic acid?

All-trans-Retinoic acid appears on 6 regulatory/inventory lists including OEHHA Proposition 65 (3/2019), OEHHA Proposition 65 (1/2023), Personal care; Southeast Asia, and 3 more. Source: EPA CPDat.

Is All-trans-Retinoic acid on the California Proposition 65 list?

Yes, All-trans-Retinoic acid is listed under California Proposition 65 for developmental. Source: California OEHHA Proposition 65.

Is All-trans-Retinoic acid used in cosmetics?

Yes, All-trans-Retinoic acid is also indexed as a cosmetic ingredient under the name Tretinoin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for All-trans-Retinoic acid come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, California Proposition 65, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is All-trans-Retinoic acid used outside industrial chemicals?

All-trans-Retinoic acid also appears in cosmetics, pharmaceutical databases.