Is Pyrroloquinoline Quinone (PQQ) safe in cosmetics?
Pyrroloquinoline Quinone (PQQ) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Pyrroloquinoline Quinone (PQQ)
Also known as: 4,5-Dihydro-4,5-dioxo-1-H-pyrrolo(2,3-f)quinoline-2,7,9-tricarboxylic acid, Pqq coenzyme, Pqq cofactor, Pyrrolo-quinoline quinone, 2,7,9-Tricarboxypyrroloquinoline quinone (+6 more)
INCI: PYRROLOQUINOLINE QUINONE
Pyrroloquinoline Quinone (PQQ) (CAS 72909-34-3) is a cosmetic cosmetic ingredient functioning as Antioxidant, Humectant, Skin conditioning, Skin protecting. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 72909-34-3 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Humectant, Skin conditioning, Skin protecting
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid
InChIKey
MMXZSJMASHPLLR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Has GRAS status as dietary ingredient; not specifically restricted in cosmetics; permitted under general provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pyrroloquinoline Quinone (PQQ).
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Pyrroloquinoline Quinone (PQQ).
Regulatory Flags
potential-allergen
Known Synonyms
4,5-Dihydro-4,5-dioxo-1-H-pyrrolo(2,3-f)quinoline-2,7,9-tricarboxylic acid
Pqq coenzyme
Pqq cofactor
Pyrrolo-quinoline quinone
2,7,9-Tricarboxypyrroloquinoline quinone
2,4,6-tricarboxylic-pyrrolo[2,3-5,6]quinoline 8,9-quinone
2,7,9-tricarboxy-1H-pyrrolo(2,3-f)quinoline-4,5-dione
4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate
4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-5,6]quinoline-2,7,9-tricarboxylic acid
PQQ
coenzyme PQQ
Chemical Function
Humectant
Antioxidant
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PYRROLOQUINOLINE QUINONE
ChEMBL ID
CHEMBL1235421
Adverse Event Associations
3
Frequently Asked Questions
Is Pyrroloquinoline Quinone (PQQ) allowed in the EU?
Pyrroloquinoline Quinone (PQQ) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pyrroloquinoline Quinone (PQQ) do in cosmetics?
Pyrroloquinoline Quinone (PQQ) functions as: Antioxidant, Humectant, Skin conditioning, Skin protecting. It is classified as a cosmetic ingredient in our database. CAS number: 72909-34-3.
Is Pyrroloquinoline Quinone (PQQ) used outside cosmetics?
Pyrroloquinoline Quinone (PQQ) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Pyrroloquinoline Quinone (PQQ) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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