Is Psicose safe in cosmetics?
Psicose has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Psicose
Also known as: Psicose, D-, D-ribo-2-Hexulose, D-Allulose
INCI: PSICOSE
Psicose (CAS 551-68-8) is a cosmetic cosmetic ingredient functioning as Humectant, Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical and food safety data.
View industrial chemical safety profile for CAS 551-68-8 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, Skin Conditioning
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(3R,4R,5R)-2-(hydroxymethyl)oxane-2,3,4,5-tetrol
InChIKey
LKDRXBCSQODPBY-JDJSBBGDSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS as food substance (FDA GRAS Notice 828); permitted in cosmetics with no restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Psicose.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Psicose.
Known Synonyms
Psicose, D-
D-ribo-2-Hexulose
D-Allulose
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1235460
SOURCE
EFSA / FDA GRAS
food_additives + fda_gras_enriched
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
D-Allulose (D-Psicose)
ADI
0.4 mg/kg bw
FDA GRAS
FDA has no questions
GRN
400
Food Category
sweetener
As a sugar substitute in the following food categories: rolls, cakes, pies, pastries, and cookies, dietetic or low calories chewing gum fat-based cream used in modified fat/calorie cookies, cakes, and pastries hard candies, low calorie (including pressed...
View full food safety profile →Frequently Asked Questions
Is Psicose allowed in the EU?
Psicose EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Psicose do in cosmetics?
Psicose functions as: Humectant, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 551-68-8.
Is Psicose used outside cosmetics?
Psicose also appears in pharmaceutical and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Psicose compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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