Food Safety Substance
D-Psicose
D-Psicose is a food additive with Not approved (EFSA 2025: safety cannot be established; novel food under review) in the EU, FDA has no questions in the US, and data from 3 regulatory sources.
CAS 551-68-8
Indexable evidence set
FDA
FDA has no questions
ADI / TDI
ADI 0.4 mg/kg bw
Codex
0 row(s)
SOURCE
D1 identity resolution
e number aliases | Food Additives | dsstox identifiers | 3 matched regulatory source group(s)
Substance Identity
Resolved identifiers used to render this food-safety record.
Substance name
D-Psicose
CAS
551-68-8
DTXSID
DTXSID201337628
PubChem CID
441036
Evidence tier
Indexable evidence set (7)
SOURCE
EU Commission
FDA | Health Canada | Codex Alimentarius
Multi-Jurisdiction Comparison
Side-by-side status rows for the same resolved substance across public food regulators.
| Jurisdiction | Authority | Status | Evidence |
|---|---|---|---|
| European Union | EU Commission | Not approved (EFSA 2025: safety cannot be established; novel food under review) | - |
| United States | FDA | FDA has no questions | GRAS notice |
SOURCE
FDA
FDA GRAS
FDA GRAS Status
US FDA GRAS notice evidence from enriched and notice tables.
| Jurisdiction | GRN | Substance | FDA response | Intended use | Basis | Notifier |
|---|---|---|---|---|---|---|
| United States | 400 | D-psicose | FDA has no questions | As a sugar substitute in the following food categories: rolls, cakes, pies, pastries, and cookies, dietetic or low calories chewing gum fat-based cream used in modified... | Scientific procedures | CJ Cheiljedang, Inc. |
| United States | 498 | D-psicose | FDA has no questions | As a sugar substitute in certain food categories | Scientific Procedures | Matustani Chemical Industry Company, Ltd. |
| United States | 647 | D-psicose | At the notifier's request, FDA ceased to evaluate this notice | For use as a sugar substitute and/or flavor modifier in food applications at use levels ranging from 1 to 100%; selected (low or reduced calorie) bakery products, alcoholic... | Scientific procedures | Samyang Corporation |
| United States | 693 | D-psicose | FDA has no questions | For use as a sugar substitute in bakery products (rolls, cakes, pastries, cakes, low calorie or dietetics); beverages (non-alcoholic), low calorie, reduced calorie, sugar-free;... | Scientific procedures | Samyang Corporation |
| United States | 755 | D-psicose | At the notifier's request, FDA ceased to evaluate this notice | For use as a sugar substitute in bakery products (rolls, cakes, pastries, cakes, low calorie or dietetics); beverages (non-alcoholic), low calorie, reduced calorie, sugar-free;... | Scientific procedures | SamYang Corp. |
| United States | 828 | D-psicose | FDA has no questions | For use as sugar substitute in bakery products (rolls, cakes, pastries, cakes, low calorie or dietetics); beverages (non-alcoholic), low calorie, reduced calorie, sugar-free;... | Scientific procedures | Samyang Corporation |
| United States | 893 | D-psicose | At the notifier's request, FDA ceased to evaluate this notice | Intended for use as a bulk sweetener in alcoholic beverages, meat and poultry products, grain-based cereal bars, dried cranberries, and pre-sweetened cereals at levels ranging... | Scientific procedures | Tate & Lyle |
| United States | 1024 | D-psicose | FDA Has no Questions | Intended for use as a sweetener at levels ranging from 2 to 100% in a variety of food categories (excluding use in infant formula, or in any products under the jurisdiction of the... | Scientific procedures | Blue California |
| United States | 1029 | D-psicose | FDA has no questions | Intended for use as an ingredient in reduced or low-calorie foods, including bakery products, chewing gums, fat-based creams, hard and soft candies, frozen dairy desserts... | Scientific procedures | L&P Food Ingredient Co., Ltd |
| United States | 1057 | D-psicose | FDA has no questions | Intended for use as a sweetener at levels ranging from 2.5 to 25% in a variety of food categories (excluding use in infant formula). The intended uses and use levels are shown in... | Scientific procedures | Tate & Lyle |
| United States | 1148 | D-psicose | FDA has no questions | Intended for use as a sweetener at levels ranging from 2.1 to 100% in a variety of food categories (excluding use in infant formula and in products under the jurisdiction of the... | Scientific procedures | Daesang Corporation |
| United States | 1188 | D-psicose | FDA has no questions | Intended for use as a sweetener at levels ranging from 2.1 to 100% in foods, including bakery products, chewing gums, fat-based creams, hard and soft candies, frozen dairy... | Scientific procedures | Shandong Starlight So True Biological Technology Co., Ltd |
| United States | 1193 | D-psicose | FDA has no questions | Intended for use as a sweetener at levels ranging from 2% to 100% in bakery products (rolls, cakes, pies, pastries, and cookies, low-calorie or dietetics); non-alcoholic beverages... | Scientific procedures | Sichuan Ingia Biosynthetic Co., Ltd. |
| United States | 400 | D-psicose | FDA has no questions | As a sugar substitute in the following food categories: <br /> <ul><li>rolls, cakes, pies, pastries, and cookies, dietetic or low calories <li>chewing gum <li>fat-based cream used... | Scientific procedures | CJ Cheiljedang, Inc. |
| United States | 498 | D-psicose | FDA has no questions | As a sugar substitute in certain food categories | Scientific Procedures | Matustani Chemical Industry Company, Ltd. |
| United States | 647 | D-psicose | At the notifier's request, FDA ceased to evaluate this notice | For use as a sugar substitute and/or flavor modifier in food applications at use levels ranging from 1 to 100%; selected (low or reduced calorie) bakery products, alcoholic... | Scientific procedures | Samyang Corporation |
| United States | 693 | D-psicose | FDA has no questions (in PDF) | For use as a sugar substitute in bakery products (rolls, cakes, pastries, cakes, low calorie or dietetics); beverages (non-alcoholic), low calorie, reduced calorie, sugar-free;... | Scientific procedures | Samyang Corporation |
| United States | 893 | D-psicose | At the notifier's request, FDA ceased to evaluate this notice (in PDF) | Intended for use as a bulk sweetener in alcoholic beverages, meat and poultry products, grain-based cereal bars, dried cranberries, and pre-sweetened cereals at levels ranging... | Scientific procedures | Tate & Lyle |
| United States | 1024 | D-psicose | FDA Has no Questions (in PDF) | Intended for use as a sweetener at levels ranging from 2 to 100% in a variety of food categories (excluding use in infant formula, or in any products under the jurisdiction of the... | Scientific procedures | Blue California |
| United States | 1029 | D-psicose | FDA has no questions (in PDF) | Intended for use as an ingredient in reduced or low-calorie foods, including bakery products, chewing gums, fat-based creams, hard and soft candies, frozen dairy desserts... | Scientific procedures | L&P Food Ingredient Co., Ltd |
| United States | 1057 | D-psicose | FDA has no questions (in PDF) | Intended for use as a sweetener at levels ranging from 2.5 to 25% in a variety of food categories (excluding use in infant formula). The intended uses and use levels are shown in... | Scientific procedures | Tate & Lyle |
| United States | 828 | D-psicose | FDA has no questions (in PDF) | For use as sugar substitute in bakery products (rolls, cakes, pastries, cakes, low calorie or dietetics); beverages (non-alcoholic), low calorie, reduced calorie, sugar-free;... | Scientific procedures | Samyang Corporation |
| United States | 755 | D-psicose | At the notifier's request, FDA ceased to evaluate this notice (in PDF) | For use as a sugar substitute in bakery products (rolls, cakes, pastries, cakes, low calorie or dietetics); beverages (non-alcoholic), low calorie, reduced calorie, sugar-free;... | Scientific procedures | SamYang Corp. |
| United States | 1148 | D-psicose | FDA has no questions (in PDF) | Intended for use as a sweetener at levels ranging from 2.1 to 100% in a variety of food categories (excluding use in infant formula and in products under the jurisdiction of the... | Scientific procedures | Daesang Corporation |
| United States | 1188 | D-psicose | FDA has no questions (in PDF) | Intended for use as a sweetener at levels ranging from 2.1 to 100% in foods, including bakery products, chewing gums, fat-based creams, hard and soft candies, frozen dairy... | Scientific procedures | Shandong Starlight So True Biological Technology Co., Ltd |
| United States | 1193 | D-psicose | FDA has no questions (in PDF) | Intended for use as a sweetener at levels ranging from 2% to 100% in bakery products (rolls, cakes, pies, pastries, and cookies, low-calorie or dietetics); non-alcoholic beverages... | Scientific procedures | Sichuan Ingia Biosynthetic Co., Ltd. |
SOURCE
ingredients
ghs classifications
Cross-Reference to Cosmetics / Chemicals / Pharma
Same-CAS public rows from adjacent Roots verticals where available.
SOURCE
Cross-vertical comparison
ingredients | ghs classifications
Cross-Vertical Regulatory Divergence
This substance has different regulatory treatment across food, cosmetics, and industrial use.
SOURCE
FAQPage JSON-LD
public food renderer rows
Frequently Asked Questions
Food-use, safety, ADI, and cross-vertical answers mirrored into FAQPage JSON-LD.
What is D-Psicose used for in food?
D-Psicose appears in food-use rows as: Sweetener.
Is D-Psicose safe?
This page does not assign a standalone safety verdict; it renders public regulatory evidence. ADI/reference value: ADI 0.4 mg/kg bw. EU status evidence: Not approved (EFSA 2025: safety cannot be established; novel food under review). US/FDA evidence: FDA has no questions.
What is the ADI for D-Psicose?
D-Psicose has this ADI/reference value in the food-safety tables: ADI 0.4 mg/kg bw. Source: FDA GRAS / EFSA: safety not established (2025 opinion).
Is D-Psicose also used in cosmetics?
D-Psicose has a same-CAS cosmetics cross-reference: Psicose, EU status permitted.