Is PROTEASE safe in cosmetics?
PROTEASE has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
PROTEASE
Also known as: Enzymes, proteolytic, Bacillus subtilis neutral protease, EINECS 232-642-4, Enzyme, proteolytic
PROTEASE (CAS 9001-92-7) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in food safety data.
View industrial chemical safety profile for CAS 9001-92-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Additional Ingredient Properties
3 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "cell-turnover, barrier-repair", "mechanism_of_action": "Enzymatic activity, targeted protein modification", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "No", "placebo_controlled": "Yes", "published_jour…
baby_pediatric
{"cas_number": "CAS-FUNC-38", "ingredient_class": "other", "pediatric_safety_rating": "good", "minimum_age_months": "3", "neonatal_safe": "no", "premature_infant_safe": "insufficient_data", "skin_barrier_maturity_consideration": "Functional ingredient - generally safe", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern…
self_tanning
{"cas_number": "9014-01-1", "ingredient_class": "tan_eraser", "tanning_mechanism": "other", "color_development_onset_hours": "0.0", "full_color_development_hours": "0", "color_duration_days": "0", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_release_concern": "no", "formaldehyde_release_ppm": "0", "AGE_formation_concern…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-stain agent
Chemical reaction regulator
Cleaning agent
Emulsifier
Flavouring and nutrient
Processing aids not otherwise specified
Softener and conditioner
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for PROTEASE.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
epa_safer_alternative
fda_food_additive
Known Synonyms
Enzymes, proteolytic
Bacillus subtilis neutral protease
EINECS 232-642-4
Enzyme, proteolytic
Chemical Function
Cleaning agent
Softener and conditioner
Chemical reaction regulator
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the...
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Protease
E Number
E1101i
Food Category
emulsifier
Frequently Asked Questions
Is PROTEASE allowed in the EU?
PROTEASE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PROTEASE do in cosmetics?
PROTEASE functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 9001-92-7.
Is PROTEASE used outside cosmetics?
PROTEASE also appears in food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check PROTEASE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Chemical family
Skin Conditioning
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Catalase
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