NOAEL Data Cosmetic Ingredient

Proteinase from B. Subtilis

Also known as: Enzymes, proteolytic, Bacillus subtilis neutral protease, EINECS 232-642-4, Enzyme, proteolytic

CAS 9001-92-7

Proteinase from B. Subtilis (CAS 9001-92-7) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for PROTEASE →

SOURCE noael studies public
NOAEL studies
2
SOURCE chemical inventory jurisdictions
Regulatory lists
5
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 7 fields
Name
Proteinase from B. Subtilis
CAS Number
9001-92-7
DTXSID
DTXSID2044185
Synonyms
Enzymes, proteolyticBacillus subtilis neutral proteaseEINECS 232-642-4Enzyme, proteolytic

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
Cleaning agentSoftener and conditionerChemical reaction regulator

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records
ListKeywordSource
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
SCIL (9/2019)USEPASafer Chemical Ingredients List

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 2 of 2 studies
ValueUnitEndpointRouteSpeciesSource
1000mg/kg bw/dayNOAELoralratCOSMOS_DB
5000mg/kg bw/dayNOAELoralratCOSMOS_DB

Showing 2 of 2 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the person introducing this chemical must tell us in writing within 28 calendar days that the circumstances have occurred. 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
View full cosmetic safety profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

E1101i — 1 food-safety record found.

View full food safety profile →

Frequently Asked Questions

What is the NOAEL for Proteinase from B. Subtilis?

Proteinase from B. Subtilis has 2 NOAEL studies in the database. The lowest reported value is 1000 mg/kg bw/day via oral in rat. Source: COSMOS_DB.

What regulatory lists include Proteinase from B. Subtilis?

Proteinase from B. Subtilis appears on 3 regulatory/inventory lists including active_ingredient; Pesticides, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), SCIL (9/2019). Source: EPA CPDat.

Is Proteinase from B. Subtilis used in cosmetics?

Yes, Proteinase from B. Subtilis is also indexed as a cosmetic ingredient under the name PROTEASE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Proteinase from B. Subtilis come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Is Proteinase from B. Subtilis used outside industrial chemicals?

Proteinase from B. Subtilis also appears in cosmetics, food safety databases.