Is Progeline (Trifluoroacetyl Tripeptide-2) — Structu safe in cosmetics?
Progeline (Trifluoroacetyl Tripeptide-2) — Structu has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Active Ingredient
Progeline (Trifluoroacetyl Tripeptide-2) — Structu
INCI: TRIFLUOROACETYL TRIPEPTIDE-2
Progeline (Trifluoroacetyl Tripeptide-2) — Structu (CAS 64577-63-5) is a cosmetic active ingredient functioning as skin conditioning and skin protecting agent. EU Regulation 1223/2009 status: permitted, max 10%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 64577-63-5 →
Auto-generated CPSR Part A draft with source citations
Function
skin conditioning and skin protecting agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2S)-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-3-methyl-2-[(2,2,2-trifluoroacetyl)amino]butanoyl]amino]propanoyl]amino]-3-methylbutanoic acid
InChIKey
SAVSLMGBKQKUAV-JYJNAYRXSA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
10%
US US Status
permitted
US Notes
CIR (Cosmetic Ingredient Review) has not published a safety assessment for Trifluoroacetyl Tripeptide-2
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Progeline (Trifluoroacetyl Tripeptide-2) — Structu.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
peptide
{"cas_number": "64577-63-5", "trade_name": "Progeline", "peptide_sequence_amino_acids": "TFA-Val-Gly-Val", "peptide_length_residues": "3", "molecular_weight_daltons": "399.3", "peptide_class": "enzyme_inhibitor", "mechanism_of_action": "Inhibits progerin synthesis, MMP inhibition, elastase inhibition", "target_protein_or_receptor": "Progerin/MMPs/elastase", "collagen_stimulation_type": "I", "colla…
Expert Verdict
Expert safety assessment and concern-level summary for Progeline (Trifluoroacetyl Tripeptide-2) — Structu.
Frequently Asked Questions
Is Progeline (Trifluoroacetyl Tripeptide-2) — Structu allowed in the EU?
Progeline (Trifluoroacetyl Tripeptide-2) — Structu EU regulatory status: permitted. Maximum allowed concentration: 10%. This is based on EU Regulation 1223/2009 and its amendments.
What does Progeline (Trifluoroacetyl Tripeptide-2) — Structu do in cosmetics?
Progeline (Trifluoroacetyl Tripeptide-2) — Structu functions as: skin conditioning and skin protecting agent. It is classified as a Active Ingredient in our database. CAS number: 64577-63-5.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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