Is Prenyl Acetate safe in cosmetics?
Prenyl Acetate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Prenyl Acetate
Also known as: 4-02-00-00185, BRN 1746265, Dimethylallyl acetate, EINECS 214-730-4, Isopent-2-enyl acetate (+2 more)
INCI: PRENYL ACETATE
Prenyl Acetate (CAS 1191-16-8) is a cosmetic cosmetic ingredient functioning as Perfuming (fragrance ingredient). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1191-16-8 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming (fragrance ingredient)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3-methylbut-2-enyl acetate
InChIKey
XXIKYCPRDXIMQM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
JECFA evaluated (No. 1827); FEMA GRAS for flavoring. Permitted in cosmetics as fragrance
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Prenyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
2326 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [26] Kligman AM (1977): Report to RIFM, 15 September, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 13500 | - | - |
| HRIPT | - | 0 | 2326 | - | - |
| HRIPT | - | 0 | 2326 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
fragrance_ifra
{"cas_number": "1191-16-8", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.13", "ifra_max_use_level_category_4_pct": "2.0", "ifra_max_use_level_category_7_pct": "0.30", "ifra_max_use_level_category_11_pct": "0.060", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_p…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1827
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
PRENYL ACETATE | 2008 | No safety concern at current levels of intake when used as a flavouring agent | ">RS 952-JECFA 69/78 | ">FAS 60-JECFA 69/291
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Prenyl Acetate.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
4-02-00-00185
BRN 1746265
Dimethylallyl acetate
EINECS 214-730-4
Isopent-2-enyl acetate
3-Methyl-2-buten-1-ol, acetate
UNII-I7KOV03HGS
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
air; Cleaning products and household care - laundry and fabric treatment; detected; emissions
air; detected; emissions; Personal care
air; Cleaning products and household care - air freshener; detected; emissions
IFRA Transparency
consumer_product
SCIL (9/2019)
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3560443
Frequently Asked Questions
Is Prenyl Acetate allowed in the EU?
Prenyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Prenyl Acetate do in cosmetics?
Prenyl Acetate functions as: Perfuming (fragrance ingredient). It is classified as a cosmetic ingredient in our database. CAS number: 1191-16-8.
Is Prenyl Acetate used outside cosmetics?
Prenyl Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Prenyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Good
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Antioxidant
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Good
Chemical family
Fragrance ingredient
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Lauryl Myristate
Excellent
Chemical family
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