Is Pregnadienol safe in cosmetics?
Pregnadienol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Pregnadienol
Also known as: 3-beta-Hydroxy-5-alpha-pregnan-20-one, 5alpha-Pregnan-20-one, 3beta-hydroxy-, Pregnan-20-one, 3-hydroxy-, (3-beta,5-alpha)-, Allopregnanolone, Isopregnanolone
INCI: PREGNADIENOL
Pregnadienol (CAS 516-55-2) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 516-55-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-[(3S,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
InChIKey
AURFZBICLPNKBZ-FZCSVUEKSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restriction for cosmetic fragrance use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pregnadienol.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Expert Verdict
Expert safety assessment and concern-level summary for Pregnadienol.
Regulatory Flags
fragrance-component
Known Synonyms
3-beta-Hydroxy-5-alpha-pregnan-20-one
5alpha-Pregnan-20-one, 3beta-hydroxy-
Pregnan-20-one, 3-hydroxy-, (3-beta,5-alpha)-
Allopregnanolone
Isopregnanolone
Frequently Asked Questions
Is Pregnadienol allowed in the EU?
Pregnadienol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pregnadienol do in cosmetics?
Pregnadienol functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 516-55-2.
Compliance Tools
Check Pregnadienol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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