Is PPG-33 safe in cosmetics?
PPG-33 has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
PPG-33
Also known as: PPG, Poly[oxy(methyl-1,2-ethanediyl)], alpha-hydro-omega-hydroxy-, 1,2-Epoxypropane polymer, PPG 20-265, EC No.: 500-039-8 (+15 more)
PPG-33 (CAS 25322-69-4) is a cosmetic cosmetic ingredient functioning as Skin conditioning, Humectant, Viscosity controlling. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 25322-69-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
PPG-33 is classified GHS Danger (H301, H302) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Skin conditioning, Humectant, Viscosity controlling
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; CIR: PPGs ≥3 safe as used when formulated to be non-irritating
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for PPG-33.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for PPG-33 across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-adhesive/cohesive
Binder
Chemical reaction regulator
Defoamer
Emulsifier
Fragrance
Hardener
Lubricating agent
Plasticizer
Processing aids not otherwise specified
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for PPG-33.
Regulatory Flags
epa_safer_alternative
ifra_fragrance
fda_food_additive
Known Synonyms
PPG
Poly[oxy(methyl-1,2-ethanediyl)], alpha-hydro-omega-hydroxy-
1,2-Epoxypropane polymer
PPG 20-265
EC No.: 500-039-8
NLP No.: 500-039-8
P.P.G. 1000
P.P.G. 1025
P.P.G. 1200
P.P.G. 1800
Actocol 51-530
Alkapal PPG-1200
Alkapal PPG-2000
Alkapal PPG-4000
Bloat guard
Caswell No. 680
EPA Pesticide Chemical Code 068602
alpha-Hydro-omega-hydroxypoly(oxy(methyl-1,2-ethanediyl))
alpha-Hydro-omega-hydroxypoly(oxypropylene)
Polyglycol P-2000
Chemical Function
Solvent
Softener and conditioner
Regulatory Lists
IFRA Transparency
drinking_water; Europe; manufacturing; plastic_additive
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe
Europe; Specialty occupational products
SCIL (9/2019)
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
POLYPROPYLENE GLYCOL (M W 1,200-3,000)
Food Category
food_additive
Frequently Asked Questions
Is PPG-33 allowed in the EU?
PPG-33 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PPG-33 do in cosmetics?
PPG-33 functions as: Skin conditioning, Humectant, Viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 25322-69-4.
Is PPG-33 used outside cosmetics?
PPG-33 also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does PPG-33 have different safety status in cosmetics vs industrial chemicals?
PPG-33 is classified GHS Danger (H301, H302) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check PPG-33 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Chemical family
Humectant, Solvent
PEG-100
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Chemical family
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