What is the NOAEL for Polypropylene glycol?
Polypropylene glycol has 73 NOAEL studies in the database. The lowest reported value is 10 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Polypropylene glycol
Also known as: PPG, Poly[oxy(methyl-1,2-ethanediyl)], alpha-hydro-omega-hydroxy-, 1,2-Epoxypropane polymer, PPG 20-265, EC No.: 500-039-8 (+15 more)
CAS 25322-69-4
Polypropylene glycol (CAS 25322-69-4) is a chemical substance. Key regulatory status: REACH registered, 12 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Polypropylene glycol is classified GHS Danger (H301, H302) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
73
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chemical inventory jurisdictions
Regulatory lists
12
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eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
23 fields
Name
Polypropylene glycol
CAS Number
25322-69-4
DTXSID
DTXSID9027863
Synonyms
PPGPoly[oxy(methyl-1,2-ethanediyl)], alpha-hydro-omega-hydroxy-1,2-Epoxypropane polymerPPG 20-265EC No.: 500-039-8NLP No.: 500-039-8P.P.G. 1000P.P.G. 1025P.P.G. 1200P.P.G. 1800Actocol 51-530Alkapal PPG-1200
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
SolventSoftener and conditionerBinderProcessing aids not otherwise specifiedPlasticizerDefoamer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
12 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Specialty occupational products | Danish Environmental Protection Agency | Danish EPA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 73 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =10 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| =98 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 01SEY4236K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 01SEY4236K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 01SEY4236K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 01SEY4236K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3C8845E7C1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3C8845E7C1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3C8845E7C1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3C8845E7C1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 439253FIWJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 439253FIWJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 439253FIWJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 439253FIWJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 757HA1493R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 757HA1493R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 757HA1493R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 757HA1493R | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9UO53X55W2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9UO53X55W2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9UO53X55W2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 9UO53X55W2 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GK69D49CJ0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GK69D49CJ0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GK69D49CJ0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GK69D49CJ0 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GS1E37J3P8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GS1E37J3P8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GS1E37J3P8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| GS1E37J3P8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H5B6JCZ906 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H5B6JCZ906 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H5B6JCZ906 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H5B6JCZ906 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| HW7M6WY97M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| HW7M6WY97M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| HW7M6WY97M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| HW7M6WY97M | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I29VQH0G0B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I29VQH0G0B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I29VQH0G0B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| I29VQH0G0B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L63N6V755Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L63N6V755Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L63N6V755Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| L63N6V755Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OV0Q322E0U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OV0Q322E0U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OV0Q322E0U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OV0Q322E0U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 50 of 73 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Propane-1,2-diol, propoxylated | 500-039-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Humectant
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Polypropylene glycol?
Polypropylene glycol appears on 9 regulatory/inventory lists including IFRA Transparency, drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Pesticides, and 6 more. Source: EPA CPDat.
Is Polypropylene glycol used in cosmetics?
Yes, Polypropylene glycol is also indexed as a cosmetic ingredient under the name PPG-33. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Polypropylene glycol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Polypropylene glycol have different safety status in cosmetics vs industrial chemicals?
Polypropylene glycol is classified GHS Danger (H301, H302) in the chemicals database but is allowed in EU cosmetics.
Is Polypropylene glycol used outside industrial chemicals?
Polypropylene glycol also appears in cosmetics, food safety, cannabis databases.