Is Polyglyceryl-4 Isostearate safe in cosmetics?
Polyglyceryl-4 Isostearate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Polyglyceryl-4 Isostearate
INCI: POLYGLYCERYL-4 ISOSTEARATE
Polyglyceryl-4 Isostearate (CAS 63705-03-3 / 91824-88-3) is a cosmetic cosmetic ingredient functioning as Skin-conditioning agent – emollient; surfactant – emulsifying agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 63705-03-3 / 91824-88-3 →
Auto-generated CPSR Part A draft with source citations
Function
Skin-conditioning agent – emollient; surfactant – emulsifying agent
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted by FDA; CIR: safe as used (2023)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Polyglyceryl-4 Isostearate.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
3 property records from structured ingredient metadata.
emulsifier
{"cas_number": "Various_4_Iso", "ingredient_class": "O/W_emulsifier", "chemical_type": "polyglycerol_ester", "HLB_value": "10.5", "HLB_required_for_oil_phase": "8-12", "emulsion_type_primary": "O/W", "droplet_size_typical_um": "2-5", "surface_tension_reduction_mN_m": "30", "interfacial_tension_reduction": "34", "foam_formation": "moderate", "foam_stability": "low", "liquid_crystal_formation": "mod…
emulsion_hlb
{"hlb_value": "5.0", "hlb_required_as_emulsifier": "yes", "emulsifier_type": "w_o", "critical_packing_parameter": "0.50-0.70", "emulsion_stabilization_mechanism": "steric_stabilization", "co_emulsifier_pairs": "cetyl_dimethicone_copolyol", "optimal_oil_phase_pct": "55-80", "optimal_water_phase_pct": "20-45", "electrolyte_tolerance": "moderate", "pH_emulsion_stability_range": "5.0-10.5", "viscosity…
solubility_hlb
{"water_soluble": "partial", "oil_soluble": "yes", "hlb_value": "8.5", "soluble_in": "oils, ethanol", "insoluble_in": "water", "log_p": "2.6", "appearance": "amber liquid", "source": "Gattefossé"}
Expert Verdict
Expert safety assessment and concern-level summary for Polyglyceryl-4 Isostearate.
Frequently Asked Questions
Is Polyglyceryl-4 Isostearate allowed in the EU?
Polyglyceryl-4 Isostearate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Polyglyceryl-4 Isostearate do in cosmetics?
Polyglyceryl-4 Isostearate functions as: Skin-conditioning agent – emollient; surfactant – emulsifying agent. It is classified as a cosmetic ingredient in our database. CAS number: 63705-03-3 / 91824-88-3.
Compliance Tools
Check Polyglyceryl-4 Isostearate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Light Stabilizer
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