NOAEL Studies Cosmetic Ingredient

POLY METHYL STYRENE ISOPROPANOL KETONE NOAEL Studies

CAS: 163702-01-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =10 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabf4e4b0a7c65d1bca39; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/5076?documentUUID=b2e01bbb-fa1e-4e08-8d0f-4da7cf000e11; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=maternal: food consumption and compound intake|maternal: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|organ weight; STUDY_GROUP=ECHA IUCLID:15822903:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9cf65258b6a6e77dab6967f8bb0a9133
ToxValDB_ECHA_IUCLID NOAEL =40 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c523d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/5076?documentUUID=b2e01bbb-fa1e-4e08-8d0f-4da7cf000e11; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=organ weight and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831566_15831567:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3558f64ab2df828366127181b620d5e6
ToxValDB_ECHA_IUCLID NOAEL =250 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabf4e4b0a7c65d1bca39; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/5076?documentUUID=b2e01bbb-fa1e-4e08-8d0f-4da7cf000e11; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15821608:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e1b5f70d4f92062fefc9b878cc09e2d
ToxValDB_ECHA_IUCLID NOEL =10 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c523d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/5076?documentUUID=b2e01bbb-fa1e-4e08-8d0f-4da7cf000e11; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=organ weight and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831566_15831567:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_990bbe699bc9bda068fc59e6de03e1dc
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =0.0521 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633534_15633535:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_70aa3cf8b379ac00745d9464f9537fbf
ToxValDB_GESTIS_DNEL DNEL systemic =1.175 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633534_15633535:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f25996c0fdb27a4b04c06134fa4b22c