Is Poloxamine 1301 safe in cosmetics?
Poloxamine 1301 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Poloxamine 1301
Also known as: Oxirane, 2-methyl-, polymer with oxirane, ether with (1,2-ethanediyldinitrilo)tetrakis[propanol] (4:1), Oxirane, polymer with methyloxirane, ether with (1,2-ethanediyldinitrilo)tetrakis[propanol] (4:1), Methyloxirane polymerise avec l'oxirane, ether (4:1) avec l'ethylenedinitrilotetrapropanol, Methyloxirane polymer with oxirane, ether with (1,2-ethanediyldinitrilo)tetrakis[propanol] (4:1), EC No.: 601-047-5
INCI: POLOXAMINE 1301
Poloxamine 1301 (CAS 11111-34-5) is a cosmetic cosmetic ingredient functioning as Surfactant – Cleansing; Surfactant – Emulsifying. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 11111-34-5 →
Auto-generated CPSR Part A draft with source citations
Function
Surfactant – Cleansing; Surfactant – Emulsifying
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA monograph; no CIR assessment
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Poloxamine 1301.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Emulsifier
Fragrance
Surfactant (surface active agent)
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Poloxamine 1301.
Regulatory Flags
ifra_fragrance
Known Synonyms
Oxirane, 2-methyl-, polymer with oxirane, ether with (1,2-ethanediyldinitrilo)tetrakis[propanol] (4:1)
Oxirane, polymer with methyloxirane, ether with (1,2-ethanediyldinitrilo)tetrakis[propanol] (4:1)
Methyloxirane polymerise avec l'oxirane, ether (4:1) avec l'ethylenedinitrilotetrapropanol
Methyloxirane polymer with oxirane, ether with (1,2-ethanediyldinitrilo)tetrakis[propanol] (4:1)
EC No.: 601-047-5
Chemical Function
Surfactant (surface active agent)
Emulsifier
Regulatory Lists
IFRA Transparency
inert_ingredient; non_food_use; Pesticides
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Poloxamine 1301 allowed in the EU?
Poloxamine 1301 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Poloxamine 1301 do in cosmetics?
Poloxamine 1301 functions as: Surfactant – Cleansing; Surfactant – Emulsifying. It is classified as a cosmetic ingredient in our database. CAS number: 11111-34-5.
Compliance Tools
Check Poloxamine 1301 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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