Is Pigment Red 57 safe in cosmetics?
Pigment Red 57 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Pigment Red 57
Also known as: Disodium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylate, C.I. Pigment Red 57, disodium salt, C.I. 15850, D&c red no.6, EINECS 227-497-9 (+7 more)
INCI: CI 15850
Pigment Red 57 (CAS 5858-81-1) is a cosmetic cosmetic ingredient functioning as Colorant (monoazo sulfonated pigment); also used as semi-permanent hair dye at. Reported NOAEL =150 mg/kg bw/day in rat (SCCNFP_vision_codex); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 5858-81-1 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant (monoazo sulfonated pigment); also used as semi-permanent hair dye at ≤0.4%
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
D&C Red No. 6 — general use including lipstick + external use; not for eye area
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pigment Red 57.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Pigment Red 57. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =150 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =150 mg/kg | oral | rat | reproductive toxicity | SCCNFP_vision_codex |
| NOAEL | =150 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =150 mg/kg | oral | rat | reproductive toxicity | SCCNFP_vision_codex |
| NOAEL | =150 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =150 mg/kg | oral | rat | reproductive toxicity | SCCNFP_vision_codex |
| NOAEL | =150 mg/kg bw/day | oral | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =150 mg/kg | oral | rat | reproductive toxicity | SCCNFP_vision_codex |
| NOAEL | = mg/kg bw/day | oral | dog | NOAEL study | SCCS_vision_codex |
| NOAEL | = mg/kg bw/day | oral | dog | NOAEL study | SCCS_vision_codex |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Hair dye substance in non-oxidative hair dye products. Max: 0,4 %.
BRIN Brazil/India Cosmetics
India: Restricted · max 0,4 %
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | All cosmetics (Class 1) |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (1 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 0.007% | - | - | SCCS/1411/11 |
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Lipstick | 1–10 | 20 | CIR/VCRP |
Additional Ingredient Properties
2 property records from structured ingredient metadata.
colorant
{"Common_Name": "D&C Red No. 7", "Chemical_Name": "Lithol Rubin B Ca", "CAS_Number": "5281-04-9", "Colorant_Type": "Synthetic Lake", "Approved_Uses": "Lipstick, external cosmetics", "Max_Concentration_%": "No limit", "EU_Status": "Not approved", "US_FDA_Status": "Approved 21 CFR 74.307", "Notes": "US only, calcium salt"}
colorant_formulator
{"ci_number": "15850", "ci_name": "Pigment Red 7", "color_category": "red", "color_hex_code": "#EA4335", "natural_or_synthetic": "synthetic", "organic_or_inorganic": "organic", "lake_or_dye": "pigment", "fda_approved_use": "general", "eu_approved_cosmetic": "yes", "japan_approved": "yes", "china_approved": "yes", "coverage_opacity": "semi_opaque", "tinting_strength": "very_high", "lightfastness_ra…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Pigment
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Pigment Red 57.
Regulatory Flags
colorant
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Pigment Red 57 by CAS number or substance name.
Studies
28
Lowest NOAEL
0
Highest NOAEL
150
Units vary across source rows: mg/kg bw/day, mg/kg bw/d, mg/kg
SCCS_vision_codex
SCCNFP_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.007% | SCCS PDF direct extraction | - |
Known Synonyms
Disodium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylate
C.I. Pigment Red 57, disodium salt
C.I. 15850
D&c red no.6
EINECS 227-497-9
Japan Red 201
Cerven pigment 57
UNII-481744AI4O
FD&C Red No. 6
disodium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate
EC No.: 227-497-9
227-497-9
Chemical Function
Pigment
Dye
Regulatory Lists
Arts and crafts/Office supplies - body paint; detected; Europe
Arts and crafts/Office supplies - body paint; detected; Europe
pharmaceutical
Personal care
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
D&C Red 6 (Lithol Rubine B)
Food Category
colorant
Frequently Asked Questions
Is Pigment Red 57 allowed in the EU?
Pigment Red 57 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pigment Red 57 do in cosmetics?
Pigment Red 57 functions as: Colorant (monoazo sulfonated pigment); also used as semi-permanent hair dye at ≤0.4%. It is classified as a cosmetic ingredient in our database. CAS number: 5858-81-1.
What is the NOAEL for Pigment Red 57?
The NOAEL (No Observed Adverse Effect Level) for Pigment Red 57 is =150 mg/kg bw/day based on a NOAEL study study via oral route in rat. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
Is Pigment Red 57 used outside cosmetics?
Pigment Red 57 also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Pigment Red 57 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acid Blue 9
Excellent
Same category
Colorant, Hair Dyeing
Acid Blue 9 Aluminum Lake
Excellent
Same category
Colorant
Anthocyanins
Excellent
Same category
Colorant
Beta Vulgaris Extract
Excellent
Same category
Skin Conditioning, Colorant (betalain...
Beta Vulgaris Root Extract
Excellent
Same category
Skin Conditioning, Colorant (betanin/...
Beta Vulgaris Root Powder
Excellent
Same category
Skin conditioning, natural colorant, ...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
CI 15630
Good
Chemical family
Colorant (red)
CI 15850
Good
Chemical family
Colorant (red)
CI 15850 Red 7 Lake
Good
Chemical family
Colorant
Is Pigment Red 57 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Pigment Red 57 in your formulation.