NOAEL Data REACH Registered Cosmetic Ingredient

C.I. Pigment Red 57

Also known as: Disodium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylate, C.I. Pigment Red 57, disodium salt, C.I. 15850, D&c red no.6, EINECS 227-497-9 (+7 more)

CAS 5858-81-1

C.I. Pigment Red 57 (CAS 5858-81-1) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for D&C Red No. 6 (CI 15850) →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 18 fields

Name

C.I. Pigment Red 57

CAS Number

5858-81-1

DTXSID

DTXSID6064038

Molecular Formula

C18H14N2O6S.2Na

InChI Key

VPWFPZBFBFHIIL-UHFFFAOYSA-L

Monoisotopic Mass

432.036796

Synonyms

Disodium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]naphthalene-2-carboxylateC.I. Pigment Red 57, disodium saltC.I. 15850D&c red no.6EINECS 227-497-9Japan Red 201Cerven pigment 57UNII-481744AI4OFD&C Red No. 6disodium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoateEC No.: 227-497-9227-497-9

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 23 records

PigmentDye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records

List	Keyword	Source
Arts and crafts/Office supplies - body paint; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Arts and crafts/Office supplies - body paint; detected; Europe	Danish Environmental Protection Agency	Danish EPA
pharmaceutical	FDA	United States Food and Drug Administration (FDA)
Personal care	FDA	United States Food and Drug Administration (FDA)
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 41 of 41 studies

Value	Unit	Endpoint	Route	Species	Source
-	mg/kg bw/day	-	oral	dog	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
0.003	mg/kg bw/d	-	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
100	mg/kg bw/day	-	-	dog	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
100	mg/kg bw/day	-	oral	dog	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
150	mg/kg bw/day	-	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies
150	mg/kg bw/day	-	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
481744AI4O	UNII	FDA UNII substance identifier	-	-	openFDA substances
481744AI4O	UNII	FDA UNII substance identifier	-	-	openFDA substances
481744AI4O	UNII	FDA UNII substance identifier	-	-	openFDA substances
481744AI4O	UNII	FDA UNII substance identifier	-	-	openFDA substances
>10800	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=-	mg/kg bw/day	NOAEL	oral	dog	SCCS_vision_codex
=-	mg/kg bw/day	NOAEL	oral	dog	SCCS_vision_codex
=-	mg/kg bw/day	NOAEL	oral	dog	SCCS_vision_codex
=-	mg/kg bw/day	NOAEL	oral	dog	SCCS_vision_codex
=0.003	mg/kg bw/d	NOAEL	-	rat	SCCS_vision_codex
=0.003	mg/kg bw/d	NOAEL	-	rat	SCCS_vision_codex
=0.003	mg/kg bw/d	NOAEL	-	rat	SCCS_vision_codex
=0.003	mg/kg bw/d	NOAEL	-	rat	SCCS_vision_codex
=100	mg/kg bw/day	NOAEL	-	dog	SCCS_vision_codex
=100	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=100	mg/kg bw/day	NOAEL	-	dog	SCCS_vision_codex
=100	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=100	mg/kg bw/day	NOAEL	-	dog	SCCS_vision_codex
=100	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=100	mg/kg bw/day	NOAEL	-	dog	SCCS_vision_codex
=100	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=150	mg/kg bw/day	NOAEL	-	rat	SCCS_vision_codex
=150	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=150	mg/kg	NOAEL	oral	rat	SCCNFP_vision_codex
=150	mg/kg bw/day	NOAEL	-	rat	SCCS_vision_codex
=150	mg/kg bw/day	NOAEL	-	rat	SCCS_vision_codex
=150	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=150	mg/kg	NOAEL	oral	rat	SCCNFP_vision_codex
=150	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=150	mg/kg	NOAEL	oral	rat	SCCNFP_vision_codex
=150	mg/kg bw/day	NOAEL	-	rat	SCCS_vision_codex
=150	mg/kg bw/day	NOAEL	oral	rat	SCCNFP_vision_codex
=150	mg/kg	NOAEL	oral	rat	SCCNFP_vision_codex
100	mg/kg bw/d	genotoxicity	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
150	mg/kg	reproductive toxicity	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies

Showing 41 of 41 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Disodium 3-hydroxy-4-[(4-methyl-2-sulphonatophenyl)azo]-2-naphthoate	227-497-9	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 1 opinions

Opinion	Date	Conclusion	Max Conc.	Concerns
SCCS/1475/12	18 September 2012	safe	0.4%	none noted

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

0.4%

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

1 food-safety record found.

View full food safety profile →

Frequently Asked Questions

What is the NOAEL for C.I. Pigment Red 57?

C.I. Pigment Red 57 has 41 NOAEL studies in the database. The lowest reported value is 0 mg/kg bw/day via oral in dog. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include C.I. Pigment Red 57?

C.I. Pigment Red 57 appears on 4 regulatory/inventory lists including Arts and crafts/Office supplies - body paint; detected; Europe, pharmaceutical, Personal care, and 1 more. Source: EPA CPDat.

Is C.I. Pigment Red 57 used in cosmetics?

Yes, C.I. Pigment Red 57 is also indexed as a cosmetic ingredient under the name D&C Red No. 6 (CI 15850). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for C.I. Pigment Red 57 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.

Is C.I. Pigment Red 57 used outside industrial chemicals?

C.I. Pigment Red 57 also appears in cosmetics, food safety databases.