Is PENTETIC ACID safe in cosmetics?
PENTETIC ACID has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
PENTETIC ACID
Also known as: 4-04-00-02454, Acetic acid, ((carboxymethylimino)bis(ethylenenitrilo))tetra-, BRN 1810219, (((Carboxymethyl)imino)bis(ethylenenitrilo))tetraacetic acid, (Diethylenetrinitrilo)pentaacetic acid (+14 more)
PENTETIC ACID (CAS 67-43-6) is a cosmetic cosmetic ingredient functioning as Chelating. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 67-43-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
PENTETIC ACID is classified GHS Danger (H319, H332, H360D, H361, H373, H360, H371, H372) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
IUPAC Name
2-[bis[2-[bis(carboxymethyl)amino]ethyl]amino]acetic acid
InChIKey
QPCDCPDFJACHGM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR: S - IJT 27(Suppl. 2):71-92, 2008
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health HazardHarmful / Irritant
Hazard Class and Category
Repr. 1B; Acute Tox. 4; STOT RE 2; Eye Irrit. 2
Hazard Statements
- H360D
- H332 Harmful if inhaled
- H373 (inhalation)
- H319 Causes serious eye irritation
Specific Concentration Limits / M-factors
Repr. 1B; H360D: C ≥ 3.0%; inhalation: ATE = 1.5 mg/L dusts or mists
Inserted via ATP: ATP18
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1720
(EU) 2023/1490
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1717
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Cleaning agent
Expert Verdict
Expert safety assessment and concern-level summary for PENTETIC ACID.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
Known Synonyms
4-04-00-02454
Acetic acid, ((carboxymethylimino)bis(ethylenenitrilo))tetra-
BRN 1810219
(((Carboxymethyl)imino)bis(ethylenenitrilo))tetraacetic acid
(Diethylenetrinitrilo)pentaacetic acid
EINECS 200-652-8
Pentacarboxymethyldiethylenetriamine
Perma kleer
Acetic acid, 2,2',2'',2'''-(((carboxymethyl)imino)bis(2,1-ethanediylnitrilo))tetrakis-
2,2'-(Carboxymethylimino)bis(ethyliminodiessigsaeure)
Acide pentetique
Acido pentetico
Acidum penteticum
UNII-7A314HQM0I
DTPA
H5dtpa
N,N,N',N'',N''-diethylenetriaminepentaacetic acid
[[(carboxymethyl)imino]bis(1,2-ethanediylnitrilo)tetraacetic acid]
diethylenetriaminepentacetic acid
Chemical Function
Chelating agent
Cleaning agent
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
inert_ingredient; non_food_use; Pesticides
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PENTETIC ACID
ChEMBL ID
CHEMBL780
Max Phase
4
Frequently Asked Questions
Is PENTETIC ACID allowed in the EU?
PENTETIC ACID EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PENTETIC ACID do in cosmetics?
PENTETIC ACID functions as: Chelating. It is classified as a cosmetic ingredient in our database. CAS number: 67-43-6.
Is PENTETIC ACID used outside cosmetics?
PENTETIC ACID also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does PENTETIC ACID have different safety status in cosmetics vs industrial chemicals?
PENTETIC ACID is classified GHS Danger (H319, H332, H360D, H361, H373, H360, H371, H372) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check PENTETIC ACID compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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