Is Pentaerythrityl Tetraethylhexanoate safe in cosmetics?
Pentaerythrityl Tetraethylhexanoate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Pentaerythrityl Tetraethylhexanoate
Also known as: Hexanoic acid, 2-ethyl-, neopentanetetrayl ester, Hexanoic acid, 2-ethyl-, 2,2-bis[[(2-ethyl-1-oxohexyl)oxy]methyl]-1,3-propanediyl ester, Hexanoic acid, 2-ethyl-, pentaerythritol tetraester, Hexanoic acid, 2-ethyl-, tetraester with pentaerythritol, Pentaerythritol, tetrakis(2-ethylhexanoate) (+13 more)
INCI: PENTAERYTHRITYL TETRAETHYLHEXANOATE
Pentaerythrityl Tetraethylhexanoate (CAS 7299-99-2) is a cosmetic emollient functioning as Skin conditioning (emollient), viscosity controlling, occlusive. Reported NOAEL =1000 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 7299-99-2 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning (emollient), viscosity controlling, occlusive
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[3-(2-ethylhexanoyloxy)-2,2-bis(2-ethylhexanoyloxymethyl)propyl] 2-ethylhexanoate
InChIKey
DRRMRHKHTQRWMB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR safe as used (2012/2015). Health Canada permits up to 50% topical.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pentaerythrityl Tetraethylhexanoate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Pentaerythrityl Tetraethylhexanoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
emulsion_hlb
{"hlb_required_as_emulsifier": "no", "hlb_required_of_oil_phase": "6-7", "co_emulsifier_pairs": "polysorbate_60,glyceryl_stearate", "optimal_oil_phase_pct": "25-50", "optimal_water_phase_pct": "50-75", "droplet_size_range_um": "5-45", "creaming_resistance": "moderate", "coalescence_resistance": "good", "ostwald_ripening_resistance": "good", "freeze_thaw_stability": "moderate", "rheology_modifier_t…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Humectant
Softener and conditioner
Thickening agent
Viscosity modifier
Expert Verdict
Expert safety assessment and concern-level summary for Pentaerythrityl Tetraethylhexanoate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Pentaerythrityl Tetraethylhexanoate by CAS number or substance name.
Studies
1
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Hexanoic acid, 2-ethyl-, neopentanetetrayl ester
Hexanoic acid, 2-ethyl-, 2,2-bis[[(2-ethyl-1-oxohexyl)oxy]methyl]-1,3-propanediyl ester
Hexanoic acid, 2-ethyl-, pentaerythritol tetraester
Hexanoic acid, 2-ethyl-, tetraester with pentaerythritol
Pentaerythritol, tetrakis(2-ethylhexanoate)
Cetiol PEEH 4
Hest P 4O
KAK-PTO
Nissan Unister H 408BRS
Pentaerythritol tetra(2-ethylhexanoate)
Pentaerythrityl tetra-2-ethylhexanoate
Pentalan 408
RA-PE 408
Salacos 5408
Trivent PE 48
Unister H 408BRS
Bis(2-ethylhexanoate) de 2,2-bis[[(2-ethyl-1-oxohexyl)oxy]methyl]propane-1,3-diyle
2,2-bis[[(2-ethyl-1-oxohexyl)oxy]methyl]propane-1,3-diyl bis(2-ethylhexanoate)
Chemical Function
Softener and conditioner
Viscosity modifier
Binder
Humectant
Thickening agent
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Pentaerythrityl Tetraethylhexanoate allowed in the EU?
Pentaerythrityl Tetraethylhexanoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pentaerythrityl Tetraethylhexanoate do in cosmetics?
Pentaerythrityl Tetraethylhexanoate functions as: Skin conditioning (emollient), viscosity controlling, occlusive. It is classified as a Emollient in our database. CAS number: 7299-99-2.
What is the NOAEL for Pentaerythrityl Tetraethylhexanoate?
The NOAEL (No Observed Adverse Effect Level) for Pentaerythrityl Tetraethylhexanoate is =1000 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Pentaerythrityl Tetraethylhexanoate used outside cosmetics?
Pentaerythrityl Tetraethylhexanoate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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