NOAEL Data REACH Registered Cosmetic Ingredient

2,2-Bis{[(2-ethylhexanoyl)oxy]methyl}propane-1,3-diyl bis(2-ethylhexanoate)

Also known as: Hexanoic acid, 2-ethyl-, neopentanetetrayl ester, Hexanoic acid, 2-ethyl-, 2,2-bis[[(2-ethyl-1-oxohexyl)oxy]methyl]-1,3-propanediyl ester, Hexanoic acid, 2-ethyl-, pentaerythritol tetraester, Hexanoic acid, 2-ethyl-, tetraester with pentaerythritol, Pentaerythritol, tetrakis(2-ethylhexanoate) (+14 more)

CAS 7299-99-2

2,2-Bis{[(2-ethylhexanoyl)oxy]methyl}propane-1,3-diyl bis(2-ethylhexanoate) (CAS 7299-99-2) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Pentaerythrityl Tetraethylhexanoate →

SOURCE noael studies public
NOAEL studies
7
SOURCE chemical inventory jurisdictions
Regulatory lists
0
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 25 fields
Name
2,2-Bis{[(2-ethylhexanoyl)oxy]methyl}propane-1,3-diyl bis(2-ethylhexanoate)
CAS Number
7299-99-2
DTXSID
DTXSID90864037
Molecular Formula
C37H68O8
InChI Key
DRRMRHKHTQRWMB-UHFFFAOYSA-N
Monoisotopic Mass
640.491419
Synonyms
Hexanoic acid, 2-ethyl-, neopentanetetrayl esterHexanoic acid, 2-ethyl-, 2,2-bis[[(2-ethyl-1-oxohexyl)oxy]methyl]-1,3-propanediyl esterHexanoic acid, 2-ethyl-, pentaerythritol tetraesterHexanoic acid, 2-ethyl-, tetraester with pentaerythritolPentaerythritol, tetrakis(2-ethylhexanoate)Cetiol PEEH 4Hest P 4OKAK-PTONissan Unister H 408BRSPentaerythritol tetra(2-ethylhexanoate)Pentaerythrityl tetra-2-ethylhexanoatePentaerythrityl tetraethylhexanoate

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 7 records
Softener and conditionerViscosity modifierBinderHumectantThickening agent

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 7 of 7 studies
ValueUnitEndpointRouteSpeciesSource
=70.52mg/m3DNEL systemicinhalationHumanToxValDB_GESTIS_DNEL
XJ7052W897UNIIFDA UNII substance identifier--openFDA substances
XJ7052W897UNIIFDA UNII substance identifier--openFDA substances
XJ7052W897UNIIFDA UNII substance identifier--openFDA substances
XJ7052W897UNIIFDA UNII substance identifier--openFDA substances
=1000mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=1000mg/kg bw/dayNOELoralRatToxValDB_ECHA_IUCLID

Showing 7 of 7 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2,2-bis[[(2-ethyl-1-oxohexyl)oxy]methyl]propane-1,3-diyl bis(2-ethylhexanoate)230-743-8ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
emollient
View full cosmetic safety profile →

Frequently Asked Questions

What is the NOAEL for 2,2-Bis{[(2-ethylhexanoyl)oxy]methyl}propane-1,3-diyl bis(2-ethylhexanoate)?

2,2-Bis{[(2-ethylhexanoyl)oxy]methyl}propane-1,3-diyl bis(2-ethylhexanoate) has 7 NOAEL studies in the database. The lowest reported value is 70.52 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

Is 2,2-Bis{[(2-ethylhexanoyl)oxy]methyl}propane-1,3-diyl bis(2-ethylhexanoate) used in cosmetics?

Yes, 2,2-Bis{[(2-ethylhexanoyl)oxy]methyl}propane-1,3-diyl bis(2-ethylhexanoate) is also indexed as a cosmetic ingredient under the name Pentaerythrityl Tetraethylhexanoate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,2-Bis{[(2-ethylhexanoyl)oxy]methyl}propane-1,3-diyl bis(2-ethylhexanoate) come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 2,2-Bis{[(2-ethylhexanoyl)oxy]methyl}propane-1,3-diyl bis(2-ethylhexanoate) used outside industrial chemicals?

2,2-Bis{[(2-ethylhexanoyl)oxy]methyl}propane-1,3-diyl bis(2-ethylhexanoate) also appears in cosmetics databases.