Is PEG-3 2,2'-DI-P-PHENYLENEDIAMINE safe in cosmetics?
PEG-3 2,2'-DI-P-PHENYLENEDIAMINE has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed. 10 toxicological study endpoint(s) are available in our database.
PEG-3 2,2'-DI-P-PHENYLENEDIAMINE
Also known as: 1,4-Benzenediamine, 2,2′-[1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]bis-, hydrochloride (1:4), 1,4-Benzenediamine, 2,2′-[1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]bis-, tetrahydrochloride
PEG-3 2,2'-DI-P-PHENYLENEDIAMINE (CAS 144644-13-3) is a cosmetic cosmetic ingredient functioning as Hair Dyeing. Reported NOAEL =10 mg/kg bw (SCCNFP_vision_codex); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 144644-13-3 →
Auto-generated CPSR Part A draft with source citations
Function
Hair Dyeing
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-[2-[2-[2-(2,5-diaminophenoxy)ethoxy]ethoxy]ethoxy]benzene-1,4-diamine;tetrahydrochloride
InChIKey
ZUCWMTGADSHOBP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
Allowed under the coal tar hair dye exemption — hair dye ingredients are exempt from color additive premarket approval requirements under FD\&C Act §601(a), provided adequate labeling and patch test warnings are included
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
10 study endpoints found for PEG-3 2,2'-DI-P-PHENYLENEDIAMINE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =10 mg/kg bw | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =10 mg/kg bw | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =10 mg/kg bw | dermal | - | repeated dose toxicity | SCCNFP_vision_codex |
| NOAEL | =45 mg/kg bw | - | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =45 mg/kg bw | - | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =45 mg/kg bw | - | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =45 mg/kg bw | - | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg bw | - | rat | dermal absorption | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg bw | - | rat | dermal absorption | SCCNFP_vision_codex |
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1234
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1234
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for PEG-3 2,2'-DI-P-PHENYLENEDIAMINE.
Regulatory Flags
cosing-sourced
eu-permitted
no-cas-assigned
needs-enrichment
eu_banned_cosmetics
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to PEG-3 2,2'-DI-P-PHENYLENEDIAMINE by CAS number or substance name.
Studies
12
Lowest NOAEL
10 mg/kg bw
Highest NOAEL
200 mg/kg bw
SCCNFP_vision_codex
Known Synonyms
1,4-Benzenediamine, 2,2′-[1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]bis-, hydrochloride (1:4)
1,4-Benzenediamine, 2,2′-[1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]bis-, tetrahydrochloride
Chemical Function
Dye
Regulatory Lists
banned; Europe; Personal care
Frequently Asked Questions
Is PEG-3 2,2'-DI-P-PHENYLENEDIAMINE allowed in the EU?
PEG-3 2,2'-DI-P-PHENYLENEDIAMINE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PEG-3 2,2'-DI-P-PHENYLENEDIAMINE do in cosmetics?
PEG-3 2,2'-DI-P-PHENYLENEDIAMINE functions as: Hair Dyeing. It is classified as a cosmetic ingredient in our database. CAS number: 144644-13-3.
What is the NOAEL for PEG-3 2,2'-DI-P-PHENYLENEDIAMINE?
The NOAEL (No Observed Adverse Effect Level) for PEG-3 2,2'-DI-P-PHENYLENEDIAMINE is =10 mg/kg bw based on a repeated dose toxicity study via dermal route in rat. A total of 10 study endpoints are available. Source: SCCNFP_vision_codex.
Compliance Tools
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Substance Compliance
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MoS Calculator
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