NOAEL Data Cosmetic Ingredient

1,8-Bis(2,5-diaminophenoxy)-3,6-dioxaoctane tetrahydrochloride

Also known as: 1,4-Benzenediamine, 2,2′-[1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]bis-, hydrochloride (1:4), 1,4-Benzenediamine, 2,2′-[1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]bis-, tetrahydrochloride

CAS 144644-13-3

1,8-Bis(2,5-diaminophenoxy)-3,6-dioxaoctane tetrahydrochloride (CAS 144644-13-3) is a chemical substance. Key regulatory status: 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for PEG-3 2,2'-DI-P-PHENYLENEDIAMINE →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 8 fields

Name

1,8-Bis(2,5-diaminophenoxy)-3,6-dioxaoctane tetrahydrochloride

CAS Number

144644-13-3

DTXSID

DTXSID20892449

Molecular Formula

C18H26N4O4.4ClH

InChI Key

ZUCWMTGADSHOBP-UHFFFAOYSA-N

Monoisotopic Mass

506.102116

Synonyms

1,4-Benzenediamine, 2,2′-[1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]bis-, hydrochloride (1:4)1,4-Benzenediamine, 2,2′-[1,2-ethanediylbis(oxy-2,1-ethanediyloxy)]bis-, tetrahydrochloride

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 1 records

List	Keyword	Source
banned; Europe; Personal care	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 17 of 17 studies

Value	Unit	Endpoint	Route	Species	Source
=10	mg/kg bw	NOAEL	dermal	-	SCCNFP_vision_codex
=10	mg/kg bw	NOAEL	dermal	-	SCCNFP_vision_codex
=10	mg/kg bw	NOAEL	dermal	-	SCCNFP_vision_codex
=10	mg/kg bw	NOAEL	dermal	-	SCCNFP_vision_codex
=45	mg/kg bw	NOAEL	-	rat	SCCNFP_vision_codex
=45	mg/kg bw	NOAEL	-	rat	SCCNFP_vision_codex
=45	mg/kg bw	NOAEL	-	rat	SCCNFP_vision_codex
=45	mg/kg bw	NOAEL	-	rat	SCCNFP_vision_codex
=200	mg/kg bw	NOAEL	-	rat	SCCNFP_vision_codex
=200	mg/kg bw	NOAEL	-	rat	SCCNFP_vision_codex
=200	mg/kg bw	NOAEL	-	rat	SCCNFP_vision_codex
=200	mg/kg bw	NOAEL	-	rat	SCCNFP_vision_codex
45	mg/kg bw	dermal absorption	-	rat	UnifiedCodex:SCCNFP:beta.noael_studies
200	mg/kg bw	dermal absorption	-	rat	UnifiedCodex:SCCNFP:beta.noael_studies
10	mg/kg bw	irritation	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies
200	mg/kg bw	irritation	oral	rat	UnifiedCodex:SCCNFP:beta.noael_studies
10	mg/kg bw	repeated dose toxicity	dermal	-	UnifiedCodex:SCCNFP:beta.noael_studies

Showing 17 of 17 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Frequently Asked Questions

What is the NOAEL for 1,8-Bis(2,5-diaminophenoxy)-3,6-dioxaoctane tetrahydrochloride?

1,8-Bis(2,5-diaminophenoxy)-3,6-dioxaoctane tetrahydrochloride has 17 NOAEL studies in the database. The lowest reported value is 10 mg/kg bw via dermal. Source: SCCNFP_vision_codex.

What regulatory lists include 1,8-Bis(2,5-diaminophenoxy)-3,6-dioxaoctane tetrahydrochloride?

1,8-Bis(2,5-diaminophenoxy)-3,6-dioxaoctane tetrahydrochloride appears on 1 regulatory/inventory list including banned; Europe; Personal care. Source: EPA CPDat.

Is 1,8-Bis(2,5-diaminophenoxy)-3,6-dioxaoctane tetrahydrochloride used in cosmetics?

Yes, 1,8-Bis(2,5-diaminophenoxy)-3,6-dioxaoctane tetrahydrochloride is also indexed as a cosmetic ingredient under the name PEG-3 2,2'-DI-P-PHENYLENEDIAMINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,8-Bis(2,5-diaminophenoxy)-3,6-dioxaoctane tetrahydrochloride come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Is 1,8-Bis(2,5-diaminophenoxy)-3,6-dioxaoctane tetrahydrochloride used outside industrial chemicals?

1,8-Bis(2,5-diaminophenoxy)-3,6-dioxaoctane tetrahydrochloride also appears in cosmetics databases.