Is PARTHENOLIDE safe in cosmetics?
PARTHENOLIDE has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
PARTHENOLIDE
Also known as: NFkB inhibitor, PTL, Germacra-1(10),11(13)-dien-12-oic acid, 4,5-alpha-epoxy-6-beta-hydroxy-, gamma-lactone, Oxireno(9,10)cyclodeca(1,2-b)furan-9(1aH)-one, 2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (1aR,4E,7aS,10aS,10bS)-, 4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone (+3 more)
PARTHENOLIDE (CAS 20554-84-1) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 20554-84-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
PARTHENOLIDE is classified GHS CMR hazard (H317, H341) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(1S,2S,4R,7E,11S)-4,8-dimethyl-12-methylidene-3,14-dioxatricyclo[9.3.0.02,4]tetradec-7-en-13-one
InChIKey
KTEXNACQROZXEV-SLXBATTESA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for PARTHENOLIDE.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
Known Synonyms
NFkB inhibitor
PTL
Germacra-1(10),11(13)-dien-12-oic acid, 4,5-alpha-epoxy-6-beta-hydroxy-, gamma-lactone
Oxireno(9,10)cyclodeca(1,2-b)furan-9(1aH)-one, 2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (1aR,4E,7aS,10aS,10bS)-
4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone
NSC 157035
(-)-Parthenolide
UNII-2RDB26I5ZB
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
Canada; pharmaceutical
Canada; pharmaceutical
Frequently Asked Questions
Is PARTHENOLIDE allowed in the EU?
PARTHENOLIDE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PARTHENOLIDE do in cosmetics?
PARTHENOLIDE functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 20554-84-1.
Is PARTHENOLIDE used outside cosmetics?
PARTHENOLIDE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does PARTHENOLIDE have different safety status in cosmetics vs industrial chemicals?
PARTHENOLIDE is classified GHS CMR hazard (H317, H341) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check PARTHENOLIDE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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