What is the NOAEL for Parthenolide?
Parthenolide has 4 NOAEL studies in the database. The lowest reported value is 2RDB26I5ZB UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Parthenolide
Also known as: NFkB inhibitor, PTL, Germacra-1(10),11(13)-dien-12-oic acid, 4,5-alpha-epoxy-6-beta-hydroxy-, gamma-lactone, Oxireno(9,10)cyclodeca(1,2-b)furan-9(1aH)-one, 2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (1aR,4E,7aS,10aS,10bS)-, 4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactone (+3 more)
CAS 20554-84-1
Parthenolide (CAS 20554-84-1) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
Cross-Vertical Regulatory Divergence
Parthenolide is classified GHS CMR hazard (H317, H341) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
NOAEL studies
NOAEL studies
4
SOURCE
Chemical inventory jurisdictions
Regulatory lists
3
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
14 fields
Name
Parthenolide
CAS Number
20554-84-1
DTXSID
DTXSID2040579
Molecular Formula
C15H20O3
InChI Key
KTEXNACQROZXEV-QLIGOWBFSA-N
Monoisotopic Mass
248.141245
Synonyms
NFkB inhibitorPTLGermacra-1(10),11(13)-dien-12-oic acid, 4,5-alpha-epoxy-6-beta-hydroxy-, gamma-lactoneOxireno(9,10)cyclodeca(1,2-b)furan-9(1aH)-one, 2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (1aR,4E,7aS,10aS,10bS)-4,5-alpha-Epoxy-6-beta-hydroxygermacra-1(10),11(13)-dien-12-oic acid gamma-lactoneNSC 157035(-)-ParthenolideUNII-2RDB26I5ZB
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2RDB26I5ZB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2RDB26I5ZB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2RDB26I5ZB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2RDB26I5ZB | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
CHEMBL465158
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
4
Frequently Asked Questions
What regulatory lists include Parthenolide?
Parthenolide appears on 2 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), Canada; pharmaceutical. Source: EPA CPDat.
Is Parthenolide used in cosmetics?
Yes, Parthenolide is also indexed as a cosmetic ingredient under the name PARTHENOLIDE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Parthenolide come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does Parthenolide have different safety status in cosmetics vs industrial chemicals?
Parthenolide is classified GHS CMR hazard (H317, H341) in the chemicals database but is allowed in EU cosmetics.
Is Parthenolide used outside industrial chemicals?
Parthenolide also appears in cosmetics, pharmaceutical databases.