Is PANTOTHENIC ACID safe in cosmetics?
PANTOTHENIC ACID has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Active Ingredient
PANTOTHENIC ACID
Also known as: D-Pantothenic acid, Pantothenic acid, D-, β-Alanine, N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, (R)-, Vitamin B3, Vitamin B5 (+12 more)
PANTOTHENIC ACID (CAS 79-83-4) is a cosmetic active ingredient functioning as Hair conditioning; skin conditioning; coenzyme A precursor; epidermal function. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 79-83-4 →
Auto-generated CPSR Part A draft with source citations
Function
Hair conditioning; skin conditioning; coenzyme A precursor; epidermal function support
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel assessed in same 1987 review as panthenol and derivatives — concluded safe in cosmetics in present practices of use and concentration. Reaffirmed after 15-year review. Coenzyme A constituent; essential for epithelial function.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for PANTOTHENIC ACID.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
3 property records from structured ingredient metadata.
baby_pediatric
{"cas_number": "79-83-4", "ingredient_class": "other", "pediatric_safety_rating": "excellent", "minimum_age_months": "0", "neonatal_safe": "yes", "premature_infant_safe": "yes", "skin_barrier_maturity_consideration": "Vitamin B5", "transepidermal_absorption_risk_pediatric": "low", "systemic_exposure_concern_pediatric": "low", "dose_per_kg_body_weight_concern": "Appropriate dosing important", "skin…
regulatory
{"eu_status": "allowed", "us_status": "allowed"}
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "recommended", "sensitive_skin": "recommended", "combination_skin": "acceptable", "normal_skin": "recommended", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "recommended", "hyperpigmentation": "acceptable", "aging_mature": "acceptable", "dehydrated": "recommended", "skin_benefit_primary": "hydrating", "skin_benefit_secondary": "wound-healin…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Softener and conditioner
Regulatory List Membership (1)
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for PANTOTHENIC ACID.
Regulatory Flags
hair-conditioning
skin-conditioning
coenzyme-a-precursor
cir-reaffirmed
panthenol-conversion-product
water-soluble
epa_safer_alternative
Known Synonyms
D-Pantothenic acid
Pantothenic acid, D-
β-Alanine, N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, (R)-
Vitamin B3
Vitamin B5
4-04-00-02569
BRN 1727064
(D,+)-N(alpha-gamma-Dihydroxy-beta,beta-dimethylbutyryl)-beta-alanine
D(+)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-beta-alanine
N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-beta-alanine
EINECS 201-229-0
Kyselina pantothenova
UNII-19F5HK2737
3-[[(2S)-2,4-dihydroxy-3,3-dimethyl-1-oxo-butyl]amino]propanoic acid
3-[[(2S)-2,4-dihydroxy-3,3-dimethyl-butanoyl]amino]propanoic acid
D-(+)-pantothenic acid
(R)-pantothenic acid
Chemical Function
Anti-static agent
Softener and conditioner
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
inert_ingredient; non_food_use; Pesticides
SCIL (9/2019)
Europe; supplements
Canada; pharmaceutical
Canada; pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
active_ingredient; animal_products; Europe; pharmaceutical; residue
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PANTOTHENIC ACID
ChEMBL ID
CHEMBL1594
Max Phase
4
Adverse Event Associations
220
Frequently Asked Questions
Is PANTOTHENIC ACID allowed in the EU?
PANTOTHENIC ACID EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PANTOTHENIC ACID do in cosmetics?
PANTOTHENIC ACID functions as: Hair conditioning; skin conditioning; coenzyme A precursor; epidermal function support. It is classified as a Active Ingredient in our database. CAS number: 79-83-4.
Is PANTOTHENIC ACID used outside cosmetics?
PANTOTHENIC ACID also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check PANTOTHENIC ACID compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Chemical family
Fragrance (perfuming)
ACRYLAMIDE
Moderate
Chemical family
Not Reported
ACRYLIC ACID
Good
Chemical family
Nail Conditioning
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