NOAEL Studies Active Ingredient

PANTHENOL NOAEL Studies

CAS: 81-13-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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CIR_vision_codex 20 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
CIR_vision_codex NOAEL =1 % rat oral 29 d repeated dose toxicity {"citation":"0; 1; 3","dose":"A study was conducted in rats fed 0 (vitamin deficient group), 0.0016%, 1%, or 3% Calcium Pantothenate daily in the diet for 29 d.65 Notable results included a decrease in body weight gain and food intake in the vitamin deficient group, an increase in brain and testis weights in the vitamin deficient group, an increase in lung and spleen weights in the an...","effect":"re statis- tically significantly lower than in all the treated groups. A study was conducted in rats fed 0 (vitamin deficient group), 0.0016%, 1%, or 3% Calcium Pantothenate daily in the diet for 29 d.65 Notable results included a decrease in body weight gain and food intake in the vitamin deficient group, an increase in brain and testis weights in the vitamin deficient group, an increase in lung and spleen weights in the animals exposed to 3%, and diarrhea at 3% concentration. A no-observed- adverse-effect-level (NOAEL) of 1% and a lowest- observed-adverse-effect-level (LOAEL) of 3% Calcium Pantothenate were reported. The same researchers performed a test of 5% Calcium Pantothenate in the diet; 4 of the 5 rats died within 2 d from severe diarrhea. Subchronic Toxicity In 3-mo subchronic toxicity studies there were no deaths reported from dermal exposure in rabbits (6 mg/cm2 of 0.5% Panthenol) and rats (227 to 680 mg/kg of 0.2% Panthenol).4 The rabbits exhibited slight to moderate erythema, edema, and Scott et al. 97S","page":21,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_001"}
CIR_vision_codex NOAEL =1 % rat oral 29 d repeated dose toxicity {"citation":"0; 1; 3","dose":"A study was conducted in rats fed 0 (vitamin deficient group), 0.0016%, 1%, or 3% Calcium Pantothenate daily in the diet for 29 d.65 Notable results included a decrease in body weight gain and food intake in the vitamin deficient group, an increase in brain and testis weights in the vitamin deficient group, an increase in lung and spleen weights in the an...","effect":"re statis- tically significantly lower than in all the treated groups. A study was conducted in rats fed 0 (vitamin deficient group), 0.0016%, 1%, or 3% Calcium Pantothenate daily in the diet for 29 d.65 Notable results included a decrease in body weight gain and food intake in the vitamin deficient group, an increase in brain and testis weights in the vitamin deficient group, an increase in lung and spleen weights in the animals exposed to 3%, and diarrhea at 3% concentration. A no-observed- adverse-effect-level (NOAEL) of 1% and a lowest- observed-adverse-effect-level (LOAEL) of 3% Calcium Pantothenate were reported. The same researchers performed a test of 5% Calcium Pantothenate in the diet; 4 of the 5 rats died within 2 d from severe diarrhea. Subchronic Toxicity In 3-mo subchronic toxicity studies there were no deaths reported from dermal exposure in rabbits (6 mg/cm2 of 0.5% Panthenol) and rats (227 to 680 mg/kg of 0.2% Panthenol).4 The rabbits exhibited slight to moderate erythema, edema, and Scott et al. 97S","page":21,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_001"}
CIR_vision_codex NOAEL =1 % rat oral 29 d repeated dose toxicity {"citation":"0; 1; 3","dose":"A study was conducted in rats fed 0 (vitamin deficient group), 0.0016%, 1%, or 3% Calcium Pantothenate daily in the diet for 29 d.65 Notable results included a decrease in body weight gain and food intake in the vitamin deficient group, an increase in brain and testis weights in the vitamin deficient group, an increase in lung and spleen weights in the an...","effect":"re statis- tically significantly lower than in all the treated groups. A study was conducted in rats fed 0 (vitamin deficient group), 0.0016%, 1%, or 3% Calcium Pantothenate daily in the diet for 29 d.65 Notable results included a decrease in body weight gain and food intake in the vitamin deficient group, an increase in brain and testis weights in the vitamin deficient group, an increase in lung and spleen weights in the animals exposed to 3%, and diarrhea at 3% concentration. A no-observed- adverse-effect-level (NOAEL) of 1% and a lowest- observed-adverse-effect-level (LOAEL) of 3% Calcium Pantothenate were reported. The same researchers performed a test of 5% Calcium Pantothenate in the diet; 4 of the 5 rats died within 2 d from severe diarrhea. Subchronic Toxicity In 3-mo subchronic toxicity studies there were no deaths reported from dermal exposure in rabbits (6 mg/cm2 of 0.5% Panthenol) and rats (227 to 680 mg/kg of 0.2% Panthenol).4 The rabbits exhibited slight to moderate erythema, edema, and Scott et al. 97S","page":21,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_001"}
CIR_vision_codex NOAEL =1 % rat oral 29 d repeated dose toxicity {"citation":"0; 1; 3","dose":"A study was conducted in rats fed 0 (vitamin deficient group), 0.0016%, 1%, or 3% Calcium Pantothenate daily in the diet for 29 d.65 Notable results included a decrease in body weight gain and food intake in the vitamin deficient group, an increase in brain and testis weights in the vitamin deficient group, an increase in lung and spleen weights in the an...","effect":"re statis- tically significantly lower than in all the treated groups. A study was conducted in rats fed 0 (vitamin deficient group), 0.0016%, 1%, or 3% Calcium Pantothenate daily in the diet for 29 d.65 Notable results included a decrease in body weight gain and food intake in the vitamin deficient group, an increase in brain and testis weights in the vitamin deficient group, an increase in lung and spleen weights in the animals exposed to 3%, and diarrhea at 3% concentration. A no-observed- adverse-effect-level (NOAEL) of 1% and a lowest- observed-adverse-effect-level (LOAEL) of 3% Calcium Pantothenate were reported. The same researchers performed a test of 5% Calcium Pantothenate in the diet; 4 of the 5 rats died within 2 d from severe diarrhea. Subchronic Toxicity In 3-mo subchronic toxicity studies there were no deaths reported from dermal exposure in rabbits (6 mg/cm2 of 0.5% Panthenol) and rats (227 to 680 mg/kg of 0.2% Panthenol).4 The rabbits exhibited slight to moderate erythema, edema, and Scott et al. 97S","page":21,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_001"}
CIR_vision_codex NOAEL =3 % rat oral 7 d oral toxicity {"citation":"0; 5; 7","dose":"sing to be 0.5% of the administered radioactivity and by 7 d 40% of the radioactivity was excreted in urine as the β-glucuronide.","effect":"sing to be 0.5% of the administered radioactivity and by 7 d 40% of the radioactivity was excreted in urine as the β-glucuronide. In rats dosed daily in the diet for 29 d with up to 3% Calcium Pantothenate, the results indicated the following: a decrease in urinary excretion of vitamins B1 and B6 me- tabolites; an increase in liver Pantothenic Acid levels with increasing Calcium Pantothenate doses; diarrhea (3% con- centration); an adverse effect on nicotinamide metabolism (0%, 1%, and 3% concentrations); and a 1% NOAEL and a 3% LOAEL. An additional test with 5% Calcium Pantothenate (oral administration) caused death in 4 of 5 rats because of severe diarrhea. In rats orally exposed to 23 mg/kg Calcium Pantothenate daily in the diet for 5 - 6 mo a 32% increase in Pantothenic Acid content in the heart and a 25% decrease in Pantothenic Acid content in the liver were observed. In hu- mans, ∼20% of a 100 mg Calcium Pantothenate oral dose was excreted in the urine within 4 h post-administration. In the body, D-Panthenol is oxidized to Pantothenic Acid. In acute dermal exposure experimen...","page":45,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_005"}
CIR_vision_codex NOAEL =3 % rat oral 7 d oral toxicity {"citation":"0; 5; 7","dose":"sing to be 0.5% of the administered radioactivity and by 7 d 40% of the radioactivity was excreted in urine as the β-glucuronide.","effect":"sing to be 0.5% of the administered radioactivity and by 7 d 40% of the radioactivity was excreted in urine as the β-glucuronide. In rats dosed daily in the diet for 29 d with up to 3% Calcium Pantothenate, the results indicated the following: a decrease in urinary excretion of vitamins B1 and B6 me- tabolites; an increase in liver Pantothenic Acid levels with increasing Calcium Pantothenate doses; diarrhea (3% con- centration); an adverse effect on nicotinamide metabolism (0%, 1%, and 3% concentrations); and a 1% NOAEL and a 3% LOAEL. An additional test with 5% Calcium Pantothenate (oral administration) caused death in 4 of 5 rats because of severe diarrhea. In rats orally exposed to 23 mg/kg Calcium Pantothenate daily in the diet for 5 - 6 mo a 32% increase in Pantothenic Acid content in the heart and a 25% decrease in Pantothenic Acid content in the liver were observed. In hu- mans, ∼20% of a 100 mg Calcium Pantothenate oral dose was excreted in the urine within 4 h post-administration. In the body, D-Panthenol is oxidized to Pantothenic Acid. In acute dermal exposure experimen...","page":45,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_005"}
CIR_vision_codex NOAEL =3 % rat oral 7 d oral toxicity {"citation":"0; 5; 7","dose":"sing to be 0.5% of the administered radioactivity and by 7 d 40% of the radioactivity was excreted in urine as the β-glucuronide.","effect":"sing to be 0.5% of the administered radioactivity and by 7 d 40% of the radioactivity was excreted in urine as the β-glucuronide. In rats dosed daily in the diet for 29 d with up to 3% Calcium Pantothenate, the results indicated the following: a decrease in urinary excretion of vitamins B1 and B6 me- tabolites; an increase in liver Pantothenic Acid levels with increasing Calcium Pantothenate doses; diarrhea (3% con- centration); an adverse effect on nicotinamide metabolism (0%, 1%, and 3% concentrations); and a 1% NOAEL and a 3% LOAEL. An additional test with 5% Calcium Pantothenate (oral administration) caused death in 4 of 5 rats because of severe diarrhea. In rats orally exposed to 23 mg/kg Calcium Pantothenate daily in the diet for 5 - 6 mo a 32% increase in Pantothenic Acid content in the heart and a 25% decrease in Pantothenic Acid content in the liver were observed. In hu- mans, ∼20% of a 100 mg Calcium Pantothenate oral dose was excreted in the urine within 4 h post-administration. In the body, D-Panthenol is oxidized to Pantothenic Acid. In acute dermal exposure experimen...","page":45,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_005"}
CIR_vision_codex NOAEL =3 % rat oral 7 d oral toxicity {"citation":"0; 5; 7","dose":"sing to be 0.5% of the administered radioactivity and by 7 d 40% of the radioactivity was excreted in urine as the β-glucuronide.","effect":"sing to be 0.5% of the administered radioactivity and by 7 d 40% of the radioactivity was excreted in urine as the β-glucuronide. In rats dosed daily in the diet for 29 d with up to 3% Calcium Pantothenate, the results indicated the following: a decrease in urinary excretion of vitamins B1 and B6 me- tabolites; an increase in liver Pantothenic Acid levels with increasing Calcium Pantothenate doses; diarrhea (3% con- centration); an adverse effect on nicotinamide metabolism (0%, 1%, and 3% concentrations); and a 1% NOAEL and a 3% LOAEL. An additional test with 5% Calcium Pantothenate (oral administration) caused death in 4 of 5 rats because of severe diarrhea. In rats orally exposed to 23 mg/kg Calcium Pantothenate daily in the diet for 5 - 6 mo a 32% increase in Pantothenic Acid content in the heart and a 25% decrease in Pantothenic Acid content in the liver were observed. In hu- mans, ∼20% of a 100 mg Calcium Pantothenate oral dose was excreted in the urine within 4 h post-administration. In the body, D-Panthenol is oxidized to Pantothenic Acid. In acute dermal exposure experimen...","page":45,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_005"}
CIR_vision_codex NOAEL =20 % mouse oral 653 days NOAEL study {"citation":"12; 57; 33","dose":"n in necropsies 12 Calcium Pantothenate Mouse/C-57 black n = 33 (treated males and females) n = 41 (control animals) 300 μg (∼20 mg/kg) Mean life span 653 days (treated) Mean life span 550 days (controls) Animals dosed daily in drinking water; untreated controls were used (no further details provided) Statistically significant increase (∼20%) in mean life...","effect":"n in necropsies 12 Calcium Pantothenate Mouse/C-57 black n = 33 (treated males and females) n = 41 (control animals) 300 μg (∼20 mg/kg) Mean life span 653 days (treated) Mean life span 550 days (controls) Animals dosed daily in drinking water; untreated controls were used (no further details provided) Statistically significant increase (∼20%) in mean life span of treated animals compared to controls; at 250 days old, body weight of treated animals were slightly higher than controls (no further details provided) 12 NOAEL = No-Observed-Adverse-Effect-Level. Scott et al. 101S","page":25,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_002"}
CIR_vision_codex NOAEL =20 % mouse oral 653 days NOAEL study {"citation":"12; 57; 33","dose":"n in necropsies 12 Calcium Pantothenate Mouse/C-57 black n = 33 (treated males and females) n = 41 (control animals) 300 μg (∼20 mg/kg) Mean life span 653 days (treated) Mean life span 550 days (controls) Animals dosed daily in drinking water; untreated controls were used (no further details provided) Statistically significant increase (∼20%) in mean life...","effect":"n in necropsies 12 Calcium Pantothenate Mouse/C-57 black n = 33 (treated males and females) n = 41 (control animals) 300 μg (∼20 mg/kg) Mean life span 653 days (treated) Mean life span 550 days (controls) Animals dosed daily in drinking water; untreated controls were used (no further details provided) Statistically significant increase (∼20%) in mean life span of treated animals compared to controls; at 250 days old, body weight of treated animals were slightly higher than controls (no further details provided) 12 NOAEL = No-Observed-Adverse-Effect-Level. Scott et al. 101S","page":25,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_002"}
CIR_vision_codex NOAEL =20 % mouse oral 653 days NOAEL study {"citation":"12; 57; 33","dose":"n in necropsies 12 Calcium Pantothenate Mouse/C-57 black n = 33 (treated males and females) n = 41 (control animals) 300 μg (∼20 mg/kg) Mean life span 653 days (treated) Mean life span 550 days (controls) Animals dosed daily in drinking water; untreated controls were used (no further details provided) Statistically significant increase (∼20%) in mean life...","effect":"n in necropsies 12 Calcium Pantothenate Mouse/C-57 black n = 33 (treated males and females) n = 41 (control animals) 300 μg (∼20 mg/kg) Mean life span 653 days (treated) Mean life span 550 days (controls) Animals dosed daily in drinking water; untreated controls were used (no further details provided) Statistically significant increase (∼20%) in mean life span of treated animals compared to controls; at 250 days old, body weight of treated animals were slightly higher than controls (no further details provided) 12 NOAEL = No-Observed-Adverse-Effect-Level. Scott et al. 101S","page":25,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_002"}
CIR_vision_codex NOAEL =20 % mouse oral 653 days NOAEL study {"citation":"12; 57; 33","dose":"n in necropsies 12 Calcium Pantothenate Mouse/C-57 black n = 33 (treated males and females) n = 41 (control animals) 300 μg (∼20 mg/kg) Mean life span 653 days (treated) Mean life span 550 days (controls) Animals dosed daily in drinking water; untreated controls were used (no further details provided) Statistically significant increase (∼20%) in mean life...","effect":"n in necropsies 12 Calcium Pantothenate Mouse/C-57 black n = 33 (treated males and females) n = 41 (control animals) 300 μg (∼20 mg/kg) Mean life span 653 days (treated) Mean life span 550 days (controls) Animals dosed daily in drinking water; untreated controls were used (no further details provided) Statistically significant increase (∼20%) in mean life span of treated animals compared to controls; at 250 days old, body weight of treated animals were slightly higher than controls (no further details provided) 12 NOAEL = No-Observed-Adverse-Effect-Level. Scott et al. 101S","page":25,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_002"}
CIR_vision_codex NOAEL =200 mg/kg/d rat oral 13-wk oral toxicity {"citation":"200; 500; (100","dose":"There were no toxicological effects reported in rats orally administered up to 200 mg/d D- and DL-Panthenol and in dogs orally dosed with up to 500 mg/d D-Panthenol.","effect":"cutaneous desquamation. The rats displayed minimal hyper- keratosis in the subcutis and skin, but no systemic toxicity was observed. There were no toxicological effects reported in rats orally administered up to 200 mg/d D- and DL-Panthenol and in dogs orally dosed with up to 500 mg/d D-Panthenol. Slight renal toxicity (100 mg/kg Panthenol) and more substantial renal toxicity (400 mg/kg Panthenol) were observed in rats orally exposed to Panthenol in a 13-wk study. Oral. A NOAEL of 200 mg/kg/d was reported for rats dosed daily in drinking water, available ad libitum, with 20, 50, or 200 mg/kg bw/d DL-Panthenol for 3 mo (OECD TG 408).6 When rats were dosed daily in diet to D-Calcium Pantothenate (up to 200 mg/kg/d) for 3 mo, adrenal gland weights were greater in males (24% increase in 50 mg/kg/d group) and lower in females (17% decrease in 200 mg/kg/d group) of treated animals compared to controls.12 A slight hyperemia of the spleen in some animals dosed with 200 mg/kg/d was also noted. Chronic Toxicity In rats orally administered 2 mg/d Panthenol for 6 mo there were no histopatholo...","page":26,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_003"}
CIR_vision_codex NOAEL =200 mg/kg/d rat oral 13-wk oral toxicity {"citation":"200; 500; (100","dose":"There were no toxicological effects reported in rats orally administered up to 200 mg/d D- and DL-Panthenol and in dogs orally dosed with up to 500 mg/d D-Panthenol.","effect":"cutaneous desquamation. The rats displayed minimal hyper- keratosis in the subcutis and skin, but no systemic toxicity was observed. There were no toxicological effects reported in rats orally administered up to 200 mg/d D- and DL-Panthenol and in dogs orally dosed with up to 500 mg/d D-Panthenol. Slight renal toxicity (100 mg/kg Panthenol) and more substantial renal toxicity (400 mg/kg Panthenol) were observed in rats orally exposed to Panthenol in a 13-wk study. Oral. A NOAEL of 200 mg/kg/d was reported for rats dosed daily in drinking water, available ad libitum, with 20, 50, or 200 mg/kg bw/d DL-Panthenol for 3 mo (OECD TG 408).6 When rats were dosed daily in diet to D-Calcium Pantothenate (up to 200 mg/kg/d) for 3 mo, adrenal gland weights were greater in males (24% increase in 50 mg/kg/d group) and lower in females (17% decrease in 200 mg/kg/d group) of treated animals compared to controls.12 A slight hyperemia of the spleen in some animals dosed with 200 mg/kg/d was also noted. Chronic Toxicity In rats orally administered 2 mg/d Panthenol for 6 mo there were no histopatholo...","page":26,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_003"}
CIR_vision_codex NOAEL =200 mg/kg/d rat oral 13-wk oral toxicity {"citation":"200; 500; (100","dose":"There were no toxicological effects reported in rats orally administered up to 200 mg/d D- and DL-Panthenol and in dogs orally dosed with up to 500 mg/d D-Panthenol.","effect":"cutaneous desquamation. The rats displayed minimal hyper- keratosis in the subcutis and skin, but no systemic toxicity was observed. There were no toxicological effects reported in rats orally administered up to 200 mg/d D- and DL-Panthenol and in dogs orally dosed with up to 500 mg/d D-Panthenol. Slight renal toxicity (100 mg/kg Panthenol) and more substantial renal toxicity (400 mg/kg Panthenol) were observed in rats orally exposed to Panthenol in a 13-wk study. Oral. A NOAEL of 200 mg/kg/d was reported for rats dosed daily in drinking water, available ad libitum, with 20, 50, or 200 mg/kg bw/d DL-Panthenol for 3 mo (OECD TG 408).6 When rats were dosed daily in diet to D-Calcium Pantothenate (up to 200 mg/kg/d) for 3 mo, adrenal gland weights were greater in males (24% increase in 50 mg/kg/d group) and lower in females (17% decrease in 200 mg/kg/d group) of treated animals compared to controls.12 A slight hyperemia of the spleen in some animals dosed with 200 mg/kg/d was also noted. Chronic Toxicity In rats orally administered 2 mg/d Panthenol for 6 mo there were no histopatholo...","page":26,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_003"}
CIR_vision_codex NOAEL =200 mg/kg/d rat oral 13-wk oral toxicity {"citation":"200; 500; (100","dose":"There were no toxicological effects reported in rats orally administered up to 200 mg/d D- and DL-Panthenol and in dogs orally dosed with up to 500 mg/d D-Panthenol.","effect":"cutaneous desquamation. The rats displayed minimal hyper- keratosis in the subcutis and skin, but no systemic toxicity was observed. There were no toxicological effects reported in rats orally administered up to 200 mg/d D- and DL-Panthenol and in dogs orally dosed with up to 500 mg/d D-Panthenol. Slight renal toxicity (100 mg/kg Panthenol) and more substantial renal toxicity (400 mg/kg Panthenol) were observed in rats orally exposed to Panthenol in a 13-wk study. Oral. A NOAEL of 200 mg/kg/d was reported for rats dosed daily in drinking water, available ad libitum, with 20, 50, or 200 mg/kg bw/d DL-Panthenol for 3 mo (OECD TG 408).6 When rats were dosed daily in diet to D-Calcium Pantothenate (up to 200 mg/kg/d) for 3 mo, adrenal gland weights were greater in males (24% increase in 50 mg/kg/d group) and lower in females (17% decrease in 200 mg/kg/d group) of treated animals compared to controls.12 A slight hyperemia of the spleen in some animals dosed with 200 mg/kg/d was also noted. Chronic Toxicity In rats orally administered 2 mg/d Panthenol for 6 mo there were no histopatholo...","page":26,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_003"}
CIR_vision_codex NOAEL =1000 mg/kg/day rat oral 6 D developmental toxicity {"citation":"6; 0, 500, 750; 1","dose":"Test Substance(s) Species/ Strain Test Population- Sex Concentration or Dosage (Vehicle) Procedure Results Reference IN VIVO Oral DL-Panthenyl Ethyl Ether Rat/Crl:","effect":"ve Toxicity (DART) Studies. Test Substance(s) Species/ Strain Test Population- Sex Concentration or Dosage (Vehicle) Procedure Results Reference IN VIVO Oral DL-Panthenyl Ethyl Ether Rat/Crl: CD(SD) n = 6 females/ group 0, 500, 750, 1000 mg/kg/day (water vehicle) Animals were dosed by gavage 1×/day on days 6 through 19 of gestation using GLP and in accordance with OECD TG 421 (Reproduction/Developmental Toxicity Screening Test); this was a screening study for OECD 414; controls were used Maternal and developmental NOAEL ≥1000 mg/kg/day was reported 6 D-Calcium Pantothenate Rat n = 20 50 or 200 mg/day (∼500 or 2000 mg/kg/day) Adult animals dosed daily in diet; weaned offspring from the 50 mg treatment group were dosed with 50 mg daily; controls were used (no further details provided) No toxicity reported; offspring weight increases were the same as controls (no further details provided) 12 Calcium Pantothenate Rat/Wistar n = not specified, females 1 mg/day (5 mg/kg/day) Adult rats were dosed daily in diet as indicated before mating and during gestation (no further details provided)...","page":27,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_004"}
CIR_vision_codex NOAEL =1000 mg/kg/day rat oral 6 D developmental toxicity {"citation":"6; 0, 500, 750; 1","dose":"Test Substance(s) Species/ Strain Test Population- Sex Concentration or Dosage (Vehicle) Procedure Results Reference IN VIVO Oral DL-Panthenyl Ethyl Ether Rat/Crl:","effect":"ve Toxicity (DART) Studies. Test Substance(s) Species/ Strain Test Population- Sex Concentration or Dosage (Vehicle) Procedure Results Reference IN VIVO Oral DL-Panthenyl Ethyl Ether Rat/Crl: CD(SD) n = 6 females/ group 0, 500, 750, 1000 mg/kg/day (water vehicle) Animals were dosed by gavage 1×/day on days 6 through 19 of gestation using GLP and in accordance with OECD TG 421 (Reproduction/Developmental Toxicity Screening Test); this was a screening study for OECD 414; controls were used Maternal and developmental NOAEL ≥1000 mg/kg/day was reported 6 D-Calcium Pantothenate Rat n = 20 50 or 200 mg/day (∼500 or 2000 mg/kg/day) Adult animals dosed daily in diet; weaned offspring from the 50 mg treatment group were dosed with 50 mg daily; controls were used (no further details provided) No toxicity reported; offspring weight increases were the same as controls (no further details provided) 12 Calcium Pantothenate Rat/Wistar n = not specified, females 1 mg/day (5 mg/kg/day) Adult rats were dosed daily in diet as indicated before mating and during gestation (no further details provided)...","page":27,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_004"}
CIR_vision_codex NOAEL =1000 mg/kg/day rat oral 6 D developmental toxicity {"citation":"6; 0, 500, 750; 1","dose":"Test Substance(s) Species/ Strain Test Population- Sex Concentration or Dosage (Vehicle) Procedure Results Reference IN VIVO Oral DL-Panthenyl Ethyl Ether Rat/Crl:","effect":"ve Toxicity (DART) Studies. Test Substance(s) Species/ Strain Test Population- Sex Concentration or Dosage (Vehicle) Procedure Results Reference IN VIVO Oral DL-Panthenyl Ethyl Ether Rat/Crl: CD(SD) n = 6 females/ group 0, 500, 750, 1000 mg/kg/day (water vehicle) Animals were dosed by gavage 1×/day on days 6 through 19 of gestation using GLP and in accordance with OECD TG 421 (Reproduction/Developmental Toxicity Screening Test); this was a screening study for OECD 414; controls were used Maternal and developmental NOAEL ≥1000 mg/kg/day was reported 6 D-Calcium Pantothenate Rat n = 20 50 or 200 mg/day (∼500 or 2000 mg/kg/day) Adult animals dosed daily in diet; weaned offspring from the 50 mg treatment group were dosed with 50 mg daily; controls were used (no further details provided) No toxicity reported; offspring weight increases were the same as controls (no further details provided) 12 Calcium Pantothenate Rat/Wistar n = not specified, females 1 mg/day (5 mg/kg/day) Adult rats were dosed daily in diet as indicated before mating and during gestation (no further details provided)...","page":27,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_004"}
CIR_vision_codex NOAEL =1000 mg/kg/day rat oral 6 D developmental toxicity {"citation":"6; 0, 500, 750; 1","dose":"Test Substance(s) Species/ Strain Test Population- Sex Concentration or Dosage (Vehicle) Procedure Results Reference IN VIVO Oral DL-Panthenyl Ethyl Ether Rat/Crl:","effect":"ve Toxicity (DART) Studies. Test Substance(s) Species/ Strain Test Population- Sex Concentration or Dosage (Vehicle) Procedure Results Reference IN VIVO Oral DL-Panthenyl Ethyl Ether Rat/Crl: CD(SD) n = 6 females/ group 0, 500, 750, 1000 mg/kg/day (water vehicle) Animals were dosed by gavage 1×/day on days 6 through 19 of gestation using GLP and in accordance with OECD TG 421 (Reproduction/Developmental Toxicity Screening Test); this was a screening study for OECD 414; controls were used Maternal and developmental NOAEL ≥1000 mg/kg/day was reported 6 D-Calcium Pantothenate Rat n = 20 50 or 200 mg/day (∼500 or 2000 mg/kg/day) Adult animals dosed daily in diet; weaned offspring from the 50 mg treatment group were dosed with 50 mg daily; controls were used (no further details provided) No toxicity reported; offspring weight increases were the same as controls (no further details provided) 12 Calcium Pantothenate Rat/Wistar n = not specified, females 1 mg/day (5 mg/kg/day) Adult rats were dosed daily in diet as indicated before mating and during gestation (no further details provided)...","page":27,"pdf":"PRS737.pdf","row_type":"noael_study","study_id":"PRS737_noael_004"}
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >10000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_10613; row=5615; data_type=In Vivo; mixture=Chemical; chemical_name=Dexpanthenol; preferred_name=Dexpanthenol; dtxsid=DTXSID3022906; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3022906; source_file=acute_oral.xlsx
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =146.9 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630951:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7f7f4844d7657da16d600580dd114a7f
UnifiedCodex:CIR:beta.noael_studies 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
UnifiedCodex:CIR:beta.noael_studies - 20 % mouse oral 653 days - SOURCE_SUBDIR=PRS737; REPORT_TITLE=Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics Laura N. Scott*, Monice Fiume**, Wilma F. Bergfeld***, Donald V. Belsito***, Ronald A. Hill****, Curtis D. Klaassen***, Daniel C. Liebler****, James G. M; OPINION_NUMBER=PRS737; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=Toxicology 2022; VALUE_TEXT=20; DOSE=n in necropsies 12 Calcium Pantothenate Mouse/C-57 black n = 33 (treated males and females) n = 41 (control animals) 300 μg (∼20 mg/kg) Mean life span 653 days (treated) Mean life span 550 days (controls) Animals dosed daily in drinking water; untreated controls were used (no further details provided) Statistically significant increase (∼20%) in mean life...; EFFECT=n in necropsies 12 Calcium Pantothenate Mouse/C-57 black n = 33 (treated males and females) n = 41 (control animals) 300 μg (∼20 mg/kg) Mean life span 653 days (treated) Mean life span 550 days (controls) Animals dosed daily in drinking water; untreated controls were used (no further details provided) Statistically significant increase (∼20%) in mean life span of treated animals compared to controls; at 250 days old, body weight of treated animals were slightly higher than controls (no further details provided) 12 NOAEL = No-Observed-Adverse-Effect-Level. Scott et al. 101S; CITATION=12; 57; 33; CITATION_NUMBERS=[12,57,33]; REFERENCE=12; 57; 33; DETAILS_JSON={"cas_number":"81-13-0","citation":"12; 57; 33","dose":"n in necropsies 12 Calcium Pantothenate Mouse/C-57 black n = 33 (treated males and females) n = 41 (control animals) 300 μg (∼20 mg/kg) Mean life span 653 days (treated) Mean life span 550 days (controls) Animals dosed daily in drinking water; untreated controls were used (no further details provided) Statistically significant increase (∼20%) in mean life...","duration":"653 days","effect":"n in necropsies 12 Calcium Pantothenate Mouse/C-57 black n = 33 (treated males and females) n = 41 (control animals) 300 μg (∼20 mg/kg) Mean life span 653 days (treated) Mean life span 550 days (controls) Animals dosed daily in drinking water; untreated controls were used (no further details provided) Statistically significant increase (∼20%) in mean life span of treated animals compared to controls; at 250 days old, body weight of treated animals were slightly higher than controls (no further details provided) 12 NOAEL = No-Observed-Adverse-Effect-Level. Scott et al. 101S","endpoint":"","ingredient":"Panthenol, Pantothenic Acid, and Derivatives","loael_value":"","noael_unit":"%","noael_value":"20","page":25,"route":"oral","species":"mouse","study_id":"PRS737_noael_002"}
UnifiedCodex:CIR:beta.noael_studies developmental toxicity >=1000 mg/kg/day rat oral 6 D developmental toxicity SOURCE_SUBDIR=PRS737; REPORT_TITLE=Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics Laura N. Scott*, Monice Fiume**, Wilma F. Bergfeld***, Donald V. Belsito***, Ronald A. Hill****, Curtis D. Klaassen***, Daniel C. Liebler****, James G. M; OPINION_NUMBER=PRS737; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=Toxicology 2022; VALUE_TEXT=≥ 1000; DOSE=Test Substance(s) Species/ Strain Test Population- Sex Concentration or Dosage (Vehicle) Procedure Results Reference IN VIVO Oral DL-Panthenyl Ethyl Ether Rat/Crl:; EFFECT=ve Toxicity (DART) Studies. Test Substance(s) Species/ Strain Test Population- Sex Concentration or Dosage (Vehicle) Procedure Results Reference IN VIVO Oral DL-Panthenyl Ethyl Ether Rat/Crl: CD(SD) n = 6 females/ group 0, 500, 750, 1000 mg/kg/day (water vehicle) Animals were dosed by gavage 1×/day on days 6 through 19 of gestation using GLP and in accordance with OECD TG 421 (Reproduction/Developmental Toxicity Screening Test); this was a screening study for OECD 414; controls were used Maternal and developmental NOAEL ≥1000 mg/kg/day was reported 6 D-Calcium Pantothenate Rat n = 20 50 or 200 mg/day (∼500 or 2000 mg/kg/day) Adult animals dosed daily in diet; weaned offspring from the 50 mg treatment group were dosed with 50 mg daily; controls were used (no further details provided) No toxicity reported; offspring weight increases were the same as controls (no further details provided) 12 Calcium Pantothenate Rat/Wistar n = not specified, females 1 mg/day (5 mg/kg/day) Adult rats were dosed daily in diet as indicated before mating and during gestation (no further details provided)...; CITATION=6; 0, 500, 750; 1; CITATION_NUMBERS=[6,500,750,1]; REFERENCE=6; 0, 500, 750; 1; DETAILS_JSON={"cas_number":"81-13-0","citation":"6; 0, 500, 750; 1","dose":"Test Substance(s) Species/ Strain Test Population- Sex Concentration or Dosage (Vehicle) Procedure Results Reference IN VIVO Oral DL-Panthenyl Ethyl Ether Rat/Crl:","duration":"6 D","effect":"ve Toxicity (DART) Studies. Test Substance(s) Species/ Strain Test Population- Sex Concentration or Dosage (Vehicle) Procedure Results Reference IN VIVO Oral DL-Panthenyl Ethyl Ether Rat/Crl: CD(SD) n = 6 females/ group 0, 500, 750, 1000 mg/kg/day (water vehicle) Animals were dosed by gavage 1×/day on days 6 through 19 of gestation using GLP and in accordance with OECD TG 421 (Reproduction/Developmental Toxicity Screening Test); this was a screening study for OECD 414; controls were used Maternal and developmental NOAEL ≥1000 mg/kg/day was reported 6 D-Calcium Pantothenate Rat n = 20 50 or 200 mg/day (∼500 or 2000 mg/kg/day) Adult animals dosed daily in diet; weaned offspring from the 50 mg treatment group were dosed with 50 mg daily; controls were used (no further details provided) No toxicity reported; offspring weight increases were the same as controls (no further details provided) 12 Calcium Pantothenate Rat/Wistar n = not specified, females 1 mg/day (5 mg/kg/day) Adult rats were dosed daily in diet as indicated before mating and during gestation (no further details provided)...","endpoint":"developmental toxicity","ingredient":"Panthenol, Pantothenic Acid, and Derivatives","loael_value":"","noael_unit":"mg/kg/day","noael_value":"≥ 1000","page":27,"route":"oral","species":"rat","study_id":"PRS737_noael_004"}
UnifiedCodex:CIR:beta.noael_studies oral toxicity 3 % rat oral 7 d oral toxicity SOURCE_SUBDIR=PRS737; REPORT_TITLE=Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics Laura N. Scott*, Monice Fiume**, Wilma F. Bergfeld***, Donald V. Belsito***, Ronald A. Hill****, Curtis D. Klaassen***, Daniel C. Liebler****, James G. M; OPINION_NUMBER=PRS737; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=Toxicology 2022; VALUE_TEXT=3; DOSE=sing to be 0.5% of the administered radioactivity and by 7 d 40% of the radioactivity was excreted in urine as the β-glucuronide.; EFFECT=sing to be 0.5% of the administered radioactivity and by 7 d 40% of the radioactivity was excreted in urine as the β-glucuronide. In rats dosed daily in the diet for 29 d with up to 3% Calcium Pantothenate, the results indicated the following: a decrease in urinary excretion of vitamins B1 and B6 me- tabolites; an increase in liver Pantothenic Acid levels with increasing Calcium Pantothenate doses; diarrhea (3% con- centration); an adverse effect on nicotinamide metabolism (0%, 1%, and 3% concentrations); and a 1% NOAEL and a 3% LOAEL. An additional test with 5% Calcium Pantothenate (oral administration) caused death in 4 of 5 rats because of severe diarrhea. In rats orally exposed to 23 mg/kg Calcium Pantothenate daily in the diet for 5 - 6 mo a 32% increase in Pantothenic Acid content in the heart and a 25% decrease in Pantothenic Acid content in the liver were observed. In hu- mans, ∼20% of a 100 mg Calcium Pantothenate oral dose was excreted in the urine within 4 h post-administration. In the body, D-Panthenol is oxidized to Pantothenic Acid. In acute dermal exposure experimen...; CITATION=0; 5; 7; CITATION_NUMBERS=[5,7]; REFERENCE=0; 5; 7; DETAILS_JSON={"cas_number":"81-13-0","citation":"0; 5; 7","dose":"sing to be 0.5% of the administered radioactivity and by 7 d 40% of the radioactivity was excreted in urine as the β-glucuronide.","duration":"7 d","effect":"sing to be 0.5% of the administered radioactivity and by 7 d 40% of the radioactivity was excreted in urine as the β-glucuronide. In rats dosed daily in the diet for 29 d with up to 3% Calcium Pantothenate, the results indicated the following: a decrease in urinary excretion of vitamins B1 and B6 me- tabolites; an increase in liver Pantothenic Acid levels with increasing Calcium Pantothenate doses; diarrhea (3% con- centration); an adverse effect on nicotinamide metabolism (0%, 1%, and 3% concentrations); and a 1% NOAEL and a 3% LOAEL. An additional test with 5% Calcium Pantothenate (oral administration) caused death in 4 of 5 rats because of severe diarrhea. In rats orally exposed to 23 mg/kg Calcium Pantothenate daily in the diet for 5 - 6 mo a 32% increase in Pantothenic Acid content in the heart and a 25% decrease in Pantothenic Acid content in the liver were observed. In hu- mans, ∼20% of a 100 mg Calcium Pantothenate oral dose was excreted in the urine within 4 h post-administration. In the body, D-Panthenol is oxidized to Pantothenic Acid. In acute dermal exposure experimen...","endpoint":"oral toxicity","ingredient":"Panthenol, Pantothenic Acid, and Derivatives","loael_value":"","noael_unit":"%","noael_value":"3","page":45,"route":"oral","species":"rat","study_id":"PRS737_noael_005"}
UnifiedCodex:CIR:beta.noael_studies oral toxicity 200 mg/kg/d rat oral 13-wk oral toxicity SOURCE_SUBDIR=PRS737; REPORT_TITLE=Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics Laura N. Scott*, Monice Fiume**, Wilma F. Bergfeld***, Donald V. Belsito***, Ronald A. Hill****, Curtis D. Klaassen***, Daniel C. Liebler****, James G. M; OPINION_NUMBER=PRS737; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=Toxicology 2022; VALUE_TEXT=200; DOSE=There were no toxicological effects reported in rats orally administered up to 200 mg/d D- and DL-Panthenol and in dogs orally dosed with up to 500 mg/d D-Panthenol.; EFFECT=cutaneous desquamation. The rats displayed minimal hyper- keratosis in the subcutis and skin, but no systemic toxicity was observed. There were no toxicological effects reported in rats orally administered up to 200 mg/d D- and DL-Panthenol and in dogs orally dosed with up to 500 mg/d D-Panthenol. Slight renal toxicity (100 mg/kg Panthenol) and more substantial renal toxicity (400 mg/kg Panthenol) were observed in rats orally exposed to Panthenol in a 13-wk study. Oral. A NOAEL of 200 mg/kg/d was reported for rats dosed daily in drinking water, available ad libitum, with 20, 50, or 200 mg/kg bw/d DL-Panthenol for 3 mo (OECD TG 408).6 When rats were dosed daily in diet to D-Calcium Pantothenate (up to 200 mg/kg/d) for 3 mo, adrenal gland weights were greater in males (24% increase in 50 mg/kg/d group) and lower in females (17% decrease in 200 mg/kg/d group) of treated animals compared to controls.12 A slight hyperemia of the spleen in some animals dosed with 200 mg/kg/d was also noted. Chronic Toxicity In rats orally administered 2 mg/d Panthenol for 6 mo there were no histopatholo...; CITATION=200; 500; (100; CITATION_NUMBERS=[200,500,100]; REFERENCE=200; 500; (100; DETAILS_JSON={"cas_number":"81-13-0","citation":"200; 500; (100","dose":"There were no toxicological effects reported in rats orally administered up to 200 mg/d D- and DL-Panthenol and in dogs orally dosed with up to 500 mg/d D-Panthenol.","duration":"13-wk","effect":"cutaneous desquamation. The rats displayed minimal hyper- keratosis in the subcutis and skin, but no systemic toxicity was observed. There were no toxicological effects reported in rats orally administered up to 200 mg/d D- and DL-Panthenol and in dogs orally dosed with up to 500 mg/d D-Panthenol. Slight renal toxicity (100 mg/kg Panthenol) and more substantial renal toxicity (400 mg/kg Panthenol) were observed in rats orally exposed to Panthenol in a 13-wk study. Oral. A NOAEL of 200 mg/kg/d was reported for rats dosed daily in drinking water, available ad libitum, with 20, 50, or 200 mg/kg bw/d DL-Panthenol for 3 mo (OECD TG 408).6 When rats were dosed daily in diet to D-Calcium Pantothenate (up to 200 mg/kg/d) for 3 mo, adrenal gland weights were greater in males (24% increase in 50 mg/kg/d group) and lower in females (17% decrease in 200 mg/kg/d group) of treated animals compared to controls.12 A slight hyperemia of the spleen in some animals dosed with 200 mg/kg/d was also noted. Chronic Toxicity In rats orally administered 2 mg/d Panthenol for 6 mo there were no histopatholo...","endpoint":"oral toxicity","ingredient":"Panthenol, Pantothenic Acid, and Derivatives","loael_value":"","noael_unit":"mg/kg/d","noael_value":"200","page":26,"route":"oral","species":"rat","study_id":"PRS737_noael_003"}
UnifiedCodex:CIR:beta.noael_studies repeated dose toxicity 1 % rat oral 29 d repeated dose toxicity SOURCE_SUBDIR=PRS737; REPORT_TITLE=Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics Laura N. Scott*, Monice Fiume**, Wilma F. Bergfeld***, Donald V. Belsito***, Ronald A. Hill****, Curtis D. Klaassen***, Daniel C. Liebler****, James G. M; OPINION_NUMBER=PRS737; COMMITTEE=Expert Panel for Cosmetic Ingredient Safety; REPORT_DATE=Toxicology 2022; VALUE_TEXT=1; DOSE=A study was conducted in rats fed 0 (vitamin deficient group), 0.0016%, 1%, or 3% Calcium Pantothenate daily in the diet for 29 d.65 Notable results included a decrease in body weight gain and food intake in the vitamin deficient group, an increase in brain and testis weights in the vitamin deficient group, an increase in lung and spleen weights in the an...; EFFECT=re statis- tically significantly lower than in all the treated groups. A study was conducted in rats fed 0 (vitamin deficient group), 0.0016%, 1%, or 3% Calcium Pantothenate daily in the diet for 29 d.65 Notable results included a decrease in body weight gain and food intake in the vitamin deficient group, an increase in brain and testis weights in the vitamin deficient group, an increase in lung and spleen weights in the animals exposed to 3%, and diarrhea at 3% concentration. A no-observed- adverse-effect-level (NOAEL) of 1% and a lowest- observed-adverse-effect-level (LOAEL) of 3% Calcium Pantothenate were reported. The same researchers performed a test of 5% Calcium Pantothenate in the diet; 4 of the 5 rats died within 2 d from severe diarrhea. Subchronic Toxicity In 3-mo subchronic toxicity studies there were no deaths reported from dermal exposure in rabbits (6 mg/cm2 of 0.5% Panthenol) and rats (227 to 680 mg/kg of 0.2% Panthenol).4 The rabbits exhibited slight to moderate erythema, edema, and Scott et al. 97S; CITATION=0; 1; 3; CITATION_NUMBERS=[1,3]; REFERENCE=0; 1; 3; DETAILS_JSON={"cas_number":"81-13-0","citation":"0; 1; 3","dose":"A study was conducted in rats fed 0 (vitamin deficient group), 0.0016%, 1%, or 3% Calcium Pantothenate daily in the diet for 29 d.65 Notable results included a decrease in body weight gain and food intake in the vitamin deficient group, an increase in brain and testis weights in the vitamin deficient group, an increase in lung and spleen weights in the an...","duration":"29 d","effect":"re statis- tically significantly lower than in all the treated groups. A study was conducted in rats fed 0 (vitamin deficient group), 0.0016%, 1%, or 3% Calcium Pantothenate daily in the diet for 29 d.65 Notable results included a decrease in body weight gain and food intake in the vitamin deficient group, an increase in brain and testis weights in the vitamin deficient group, an increase in lung and spleen weights in the animals exposed to 3%, and diarrhea at 3% concentration. A no-observed- adverse-effect-level (NOAEL) of 1% and a lowest- observed-adverse-effect-level (LOAEL) of 3% Calcium Pantothenate were reported. The same researchers performed a test of 5% Calcium Pantothenate in the diet; 4 of the 5 rats died within 2 d from severe diarrhea. Subchronic Toxicity In 3-mo subchronic toxicity studies there were no deaths reported from dermal exposure in rabbits (6 mg/cm2 of 0.5% Panthenol) and rats (227 to 680 mg/kg of 0.2% Panthenol).4 The rabbits exhibited slight to moderate erythema, edema, and Scott et al. 97S","endpoint":"repeated dose toxicity","ingredient":"Panthenol, Pantothenic Acid, and Derivatives","loael_value":"","noael_unit":"%","noael_value":"1","page":21,"route":"oral","species":"rat","study_id":"PRS737_noael_001"}
openFDA substances 12 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier WV9CM0O67Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H19NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WV9CM0O67Z"}
openFDA substances FDA UNII substance identifier WV9CM0O67Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H19NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WV9CM0O67Z"}
openFDA substances FDA UNII substance identifier WV9CM0O67Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H19NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WV9CM0O67Z"}
openFDA substances FDA UNII substance identifier WV9CM0O67Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H19NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WV9CM0O67Z"}
openFDA substances FDA UNII substance identifier WV9CM0O67Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H19NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WV9CM0O67Z"}
openFDA substances FDA UNII substance identifier WV9CM0O67Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H19NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WV9CM0O67Z"}
openFDA substances FDA UNII substance identifier WV9CM0O67Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H19NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WV9CM0O67Z"}
openFDA substances FDA UNII substance identifier WV9CM0O67Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H19NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"WV9CM0O67Z"}
openFDA substances FDA UNII substance identifier 1O6C93RI7Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H19NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1O6C93RI7Z"}
openFDA substances FDA UNII substance identifier 1O6C93RI7Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H19NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1O6C93RI7Z"}
openFDA substances FDA UNII substance identifier 1O6C93RI7Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H19NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1O6C93RI7Z"}
openFDA substances FDA UNII substance identifier 1O6C93RI7Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H19NO4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"1O6C93RI7Z"}