Is PANTHENOL safe in cosmetics?
PANTHENOL has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Active Ingredient
PANTHENOL
PANTHENOL (CAS 81-13-0) is a cosmetic active ingredient functioning as Humectant; hair conditioner; barrier support. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 81-13-0 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant; hair conditioner; barrier support
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; no US concentration cap. Effective at 2–5% in leave-on formulations. CIR reviewed and confirmed safe as used. Widely used in sensitive-skin, baby-care, and wound-healing formulations.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for PANTHENOL.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for PANTHENOL.
Regulatory Flags
active
barrier-repair
soothing
anti-inflammatory
humectant
coenzyme-a-precursor
il-6-il-8-inhibitor
provitamin
sensitive-skin
baby-safe
2-5pct-effective-dose
eu_children_restricted
epa_safer_alternative
ifra_fragrance
fda_food_additive
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DEXPANTHENOL
ChEMBL ID
CHEMBL1200979
Max Phase
4
Adverse Event Associations
1990
Frequently Asked Questions
Is PANTHENOL allowed in the EU?
PANTHENOL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PANTHENOL do in cosmetics?
PANTHENOL functions as: Humectant; hair conditioner; barrier support. It is classified as a Active Ingredient in our database. CAS number: 81-13-0.
Is PANTHENOL used outside cosmetics?
PANTHENOL also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check PANTHENOL compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Is PANTHENOL in Your Products?
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Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for PANTHENOL in your formulation.