Is PANTETHINE safe in cosmetics?
PANTETHINE has a safety rating of "GOOD" in our database. EU status: permitted. US status: prohibited.
PANTETHINE
Also known as: Butanamide, N,N'-[dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethyl-, (2R,2'R)-, (2R,2'R)-N,N'-[Dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethylbutanamide], D-Bis(N-pantothenyl-beta-aminoethyl) disulfide, EINECS 240-842-8, UNII-7K81IL792L
PANTETHINE (CAS 16816-67-4) is a cosmetic cosmetic ingredient functioning as Hair Conditioning, Skin Conditioning - Emollient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 16816-67-4 →
Auto-generated CPSR Part A draft with source citations
Function
Hair Conditioning, Skin Conditioning - Emollient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2R)-N-[3-[2-[2-[3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyldisulfanyl]ethylamino]-3-oxopropyl]-2,4-dihydroxy-3,3-dimethylbutanamide
InChIKey
DJWYOLJPSHDSAL-ROUUACIJSA-N
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Allowed — not prohibited or restricted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Dermal Penetration Profile
Skin absorption and penetration characteristics of PANTETHINE, relevant to systemic exposure and MoS calculations.
Absorption %
5-10%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum/epidermis
Molecular Weight
278.4 Da
Log P
-1.5
Systemic Absorption
minimal
Topical Bioavailability
3-8%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation
Source: Cosmetic Science
Additional Ingredient Properties
1 property record from structured ingredient metadata.
dermal_absorption
{"molecular_weight_da": "278.4", "log_p_value": "-1.5", "skin_penetration_level": "stratum-corneum", "penetration_depth": "stratum corneum/epidermis", "absorption_pct": "5-10", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "3-8", "safety_margin_factor": "low"…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for PANTETHINE.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
hair-conditioning
emollient
needs-enrichment
Known Synonyms
Butanamide, N,N'-[dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethyl-, (2R,2'R)-
(2R,2'R)-N,N'-[Dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethylbutanamide]
D-Bis(N-pantothenyl-beta-aminoethyl) disulfide
EINECS 240-842-8
UNII-7K81IL792L
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Canada; Personal care; Substances in PCP - Canada (4/2014)
Europe; supplements
Canada; pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PANTETHINE
ChEMBL ID
CHEMBL2104786
Max Phase
3
Adverse Event Associations
58
Frequently Asked Questions
Is PANTETHINE allowed in the EU?
PANTETHINE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PANTETHINE do in cosmetics?
PANTETHINE functions as: Hair Conditioning, Skin Conditioning - Emollient. It is classified as a cosmetic ingredient in our database. CAS number: 16816-67-4.
Is PANTETHINE used outside cosmetics?
PANTETHINE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check PANTETHINE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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