What is the NOAEL for Pantethine?
Pantethine has 7 NOAEL studies in the database. The lowest reported value is 7K81IL792L UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Pantethine
Also known as: Butanamide, N,N'-[dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethyl-, (2R,2'R)-, (2R,2'R)-N,N'-[Dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethylbutanamide], D-Bis(N-pantothenyl-beta-aminoethyl) disulfide, EINECS 240-842-8, UNII-7K81IL792L
CAS 16816-67-4
Pantethine (CAS 16816-67-4) is a chemical substance. Key regulatory status: 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
Pantethine
CAS Number
16816-67-4
DTXSID
DTXSID9046815
Molecular Formula
C22H42N4O8S2
InChI Key
DJWYOLJPSHDSAL-ROUUACIJSA-N
Monoisotopic Mass
554.244407
Synonyms
Butanamide, N,N'-[dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethyl-, (2R,2'R)-(2R,2'R)-N,N'-[Dithiobis[2,1-ethanediylimino(3-oxo-3,1-propanediyl)]]bis[2,4-dihydroxy-3,3-dimethylbutanamide]D-Bis(N-pantothenyl-beta-aminoethyl) disulfideEINECS 240-842-8UNII-7K81IL792L
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| Europe; supplements | EU | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 7K81IL792L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7K81IL792L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7K81IL792L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7K81IL792L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =36 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =36 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =36 | mg/kg bw/day | NOAEL | - | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Showing 7 of 7 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Emollient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PANTETHINE
ChEMBL Phase
3
Adverse Events
58
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Pantethine?
Pantethine appears on 3 regulatory/inventory lists including Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; supplements, Canada; pharmaceutical. Source: EPA CPDat.
Is Pantethine used in cosmetics?
Yes, Pantethine is also indexed as a cosmetic ingredient under the name PANTETHINE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Pantethine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Pantethine used outside industrial chemicals?
Pantethine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.