Is Palmitoyl Tripeptide-38 safe in cosmetics?
Palmitoyl Tripeptide-38 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Palmitoyl Tripeptide-38
INCI: PALMITOYL TRIPEPTIDE-38
Palmitoyl Tripeptide-38 (CAS 1101175-36-3 (active); also cited as 1447824-23-8 in some sources) is a cosmetic cosmetic ingredient functioning as Anti-wrinkle, anti-aging matrikine-mimetic; regulates cell activity, wound. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
1101175-36-3 (active); also cited as 1447824-23-8 in some sources
View industrial chemical safety profile →
Function
Anti-wrinkle, anti-aging matrikine-mimetic; regulates cell activity, wound repair, and tissue remodeling
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted; CIR group review applies
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Palmitoyl Tripeptide-38.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
5 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "firming, collagen-boosting", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Yes", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "18-28", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, Int J Pept Re…
peptide
{"cas_number": "1447824-23-8", "trade_name": "Matrixyl Synthe 6", "peptide_sequence_amino_acids": "Pal-Lys-Met-Lys", "peptide_length_residues": "3", "molecular_weight_daltons": "635.9", "peptide_class": "signal", "mechanism_of_action": "Stimulates 6 major components of dermal matrix and DEJ (collagen I/III/IV, fibronectin, hyaluronic acid, laminin-5)", "target_protein_or_receptor": "Syndecan/Integ…
stability
{"shelf_life_months": "12", "shelf_life_opened_months": "3", "storage_temp_min_c": "2", "storage_temp_max_c": "8", "light_sensitive": "moderate", "air_sensitive": "yes", "moisture_sensitive": "yes", "oxidation_prone": "no", "requires_nitrogen_blanket": "no", "stability_indicator": "moderate", "degradation_products": "fatty acid, peptide fragments", "recommended_packaging": "airless pump, refrigera…
synergy
{"inci_name_2": "Acetyl Hexapeptide-8 + Vitamin C", "synergy_type": "efficacy-boost", "synergy_description": "Wrinkle-filling with muscle relaxing and collagen support for maximum wrinkle reduction", "combined_benefit": "Superior wrinkle reduction, muscle relaxation + filling + collagen support", "efficacy_multiplier": "3.4x", "mechanism_of_action": "Synthe 6 fills wrinkles; argireline relaxes mus…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "yes", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "5", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv":…
Expert Verdict
Expert safety assessment and concern-level summary for Palmitoyl Tripeptide-38.
Frequently Asked Questions
Is Palmitoyl Tripeptide-38 allowed in the EU?
Palmitoyl Tripeptide-38 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Palmitoyl Tripeptide-38 do in cosmetics?
Palmitoyl Tripeptide-38 functions as: Anti-wrinkle, anti-aging matrikine-mimetic; regulates cell activity, wound repair, and tissue remodeling. It is classified as a cosmetic ingredient in our database. CAS number: 1101175-36-3 (active); also cited as 1447824-23-8 in some sources.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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Not Reported
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