Is Paeoniflorin safe in cosmetics?
Paeoniflorin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Paeoniflorin
Also known as: Paeoniae radix root, EINECS 245-476-2, beta-D-Glucopyranoside, (1aS,2R,3aR,5R,5aR,5bS)-5b-((benzoyloxy)methyl)tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta(cd)pentalen-1a(2H)-yl, Paeonia moutan, Paeony root (+1 more)
INCI: PAEONIFLORIN
Paeoniflorin (CAS 23180-57-6) is a cosmetic cosmetic ingredient functioning as Anti-inflammatory, Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 23180-57-6 →
Auto-generated CPSR Part A draft with source citations
Function
Anti-inflammatory, Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[(1R,2S,3R,5R,6R,8S)-6-hydroxy-8-methyl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9,10-dioxatetracyclo[4.3.1.02,5.03,8]decan-2-yl]methyl benzoate
InChIKey
YKRGDOXKVOZESV-WRJNSLSBSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — Listed in CTFA/PCPC dictionary; no FDA restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Paeoniflorin.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Expert Verdict
Expert safety assessment and concern-level summary for Paeoniflorin.
Known Synonyms
Paeoniae radix root
EINECS 245-476-2
beta-D-Glucopyranoside, (1aS,2R,3aR,5R,5aR,5bS)-5b-((benzoyloxy)methyl)tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta(cd)pentalen-1a(2H)-yl
Paeonia moutan
Paeony root
UNII-21AIQ4EV64
Chemical Function
Humectant
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PAEONIFLORIN
ChEMBL ID
CHEMBL4303209
Max Phase
3
Frequently Asked Questions
Is Paeoniflorin allowed in the EU?
Paeoniflorin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Paeoniflorin do in cosmetics?
Paeoniflorin functions as: Anti-inflammatory, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 23180-57-6.
Is Paeoniflorin used outside cosmetics?
Paeoniflorin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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