Is Gamma-Oryzanol safe in cosmetics?
Gamma-Oryzanol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Gamma-Oryzanol
Also known as: HI-Z, OZ, Oliver, gamma-OZ, Gammajust 50 (+11 more)
INCI: ORYZANOL
Gamma-Oryzanol (CAS 11042-64-1) is a cosmetic cosmetic ingredient functioning as Antioxidant; UV Absorber; Skin Conditioning; Antistat. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 11042-64-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Gamma-Oryzanol is classified GHS Danger (H310) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant; UV Absorber; Skin Conditioning; Antistat
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
[(1S,3R,6S,8R,11S,12S,15R,16R)-7,7,12,16-tetramethyl-15-[(2R)-6-methylhept-5-en-2-yl]-6-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
InChIKey
FODTZLFLDFKIQH-FSVGXZBPSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not a permitted OTC sunscreen active under 21 CFR 352; permitted as cosmetic antioxidant/skin conditioning; CIR assessed Oryza Sativa-derived ingredients safe (2006)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Gamma-Oryzanol.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Gamma-Oryzanol.
Regulatory Flags
antioxidant
uv-absorber
plant-derived
rice-bran
oil-soluble
no-sccs-opinion
cir-assessed
cannot-claim-spf-us
Known Synonyms
HI-Z
OZ
Oliver
gamma-OZ
Gammajust 50
gamma-Orizanol
Maspiron
Oryvita
Thiaminogen
Caclate
Gammatsul
Guntrin
Oryzaal
Gammariza
UNII-SST9XCL51M
Gamma oryzanol
Regulatory Lists
active_ingredient; Australia
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
49
Frequently Asked Questions
Is Gamma-Oryzanol allowed in the EU?
Gamma-Oryzanol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Gamma-Oryzanol do in cosmetics?
Gamma-Oryzanol functions as: Antioxidant; UV Absorber; Skin Conditioning; Antistat. It is classified as a cosmetic ingredient in our database. CAS number: 11042-64-1.
Is Gamma-Oryzanol used outside cosmetics?
Gamma-Oryzanol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Gamma-Oryzanol have different safety status in cosmetics vs industrial chemicals?
Gamma-Oryzanol is classified GHS Danger (H310) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Gamma-Oryzanol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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