Is OCTYLISOTHIAZOLINONE safe in cosmetics?
OCTYLISOTHIAZOLINONE has a safety rating of "GOOD" in our database. EU status: permitted.
OCTYLISOTHIAZOLINONE
Also known as: 2-Octyl-3-isothiazolone, BRN 1211137, Caswell No. 613C, EINECS 247-761-7, EPA Pesticide Chemical Code 099901 (+8 more)
OCTYLISOTHIAZOLINONE (CAS 26530-20-1) is a cosmetic cosmetic ingredient functioning as Antimicrobial. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 26530-20-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
OCTYLISOTHIAZOLINONE is classified GHS Danger (H301, H302, H311, H314, H317, H318, H330, H331) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antimicrobial
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-octyl-1,2-thiazol-3-one
InChIKey
JPMIIZHYYWMHDT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Sensitization Profile
Contact sensitization data for OCTYLISOTHIAZOLINONE based on clinical patch test studies and IFRA standards.
Sensitization Rate
moderate
Allergen Class
preservative
EU Allergen Listed
no
Patch Test Positive Rate
1.0%
Cross-reactivity Group
isothiazolinone-group
Reaction Type
contact-dermatitis
Source: NACDG 2021-22; ESSCA 2019/20
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Acute ToxicityCorrosiveEnvironmental Hazard
Hazard Class and Category
Acute Tox. 2; Acute Tox. 3; Acute Tox. 3; Skin Corr. 1; Eye Dam. 1; Skin Sens. 1A; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H330 Fatal if inhaled
- H311 Toxic in contact with skin
- H301 Toxic if swallowed
- H314 Causes severe skin burns and eye damage
- H318 Causes serious eye damage
- H317 May cause an allergic skin reaction
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
inhalation: ATE = 0.27 mg/L dusts or mists; dermal: ATE = 311.0 mg/kg bw; oral: ATE = 125.0 mg/kg bw; Skin Sens. 1A; H317: C ≥ 0.0015%; M = 100; M = 100
Inserted via ATP: ATP15
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "preservative", "cross_reactivity_group": "isothiazolinone-group", "patch_test_frequency_pct": "1.0", "sensitization_rate": "moderate", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "NACDG 2021-22; ESSCA 2019/20"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
A skin and severe eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Biocide
Preservative
Regulatory List Membership (1)
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for OCTYLISOTHIAZOLINONE.
Regulatory Flags
cosing-sourced
eu-permitted
preservative
needs-enrichment
epa_safer_alternative
Known Synonyms
2-Octyl-3-isothiazolone
BRN 1211137
Caswell No. 613C
EINECS 247-761-7
EPA Pesticide Chemical Code 099901
Microbicide M-8
Micro-chek skane
Pancil-T
Vinylzene IT 3000DIDP
UNII-4LFS24GD0V
2-Octyl-3-isothioazolone
Octyl-3(2H)-isothiazolone
Octyl-4-isothiazol-3-one
Chemical Function
Preservative
Biocide
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Europe; Pesticides
SCIL (9/2019)
Europe; nondetect; Other direct contact consumer goods
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1562104
Frequently Asked Questions
Is OCTYLISOTHIAZOLINONE allowed in the EU?
OCTYLISOTHIAZOLINONE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does OCTYLISOTHIAZOLINONE do in cosmetics?
OCTYLISOTHIAZOLINONE functions as: Antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 26530-20-1.
Is OCTYLISOTHIAZOLINONE used outside cosmetics?
OCTYLISOTHIAZOLINONE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does OCTYLISOTHIAZOLINONE have different safety status in cosmetics vs industrial chemicals?
OCTYLISOTHIAZOLINONE is classified GHS Danger (H301, H302, H311, H314, H317, H318, H330, H331) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check OCTYLISOTHIAZOLINONE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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