Danger GHS06GHS05GHS09 NOAEL Data REACH Registered Cosmetic Ingredient

Octhilinone

Also known as: 2-Octyl-3-isothiazolone, BRN 1211137, Caswell No. 613C, EINECS 247-761-7, EPA Pesticide Chemical Code 099901 (+8 more)

CAS 26530-20-1

Octhilinone (CAS 26530-20-1) is a chemical substance with GHS signal word Danger; key hazard signal: H330; H311; H301; H314; H318; H317; H400; H410. Key regulatory status: REACH registered, 34 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for OCTYLISOTHIAZOLINONE →

SOURCE noael studies public
NOAEL studies
77
SOURCE chemical inventory jurisdictions
Regulatory lists
34
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields
Name
Octhilinone
CAS Number
26530-20-1
DTXSID
DTXSID1025805
Molecular Formula
C11H19NOS
InChI Key
JPMIIZHYYWMHDT-UHFFFAOYSA-N
Monoisotopic Mass
213.118735
Synonyms
2-Octyl-3-isothiazoloneBRN 1211137Caswell No. 613CEINECS 247-761-7EPA Pesticide Chemical Code 099901Microbicide M-8Micro-chek skanePancil-TVinylzene IT 3000DIDPUNII-4LFS24GD0V2-Octyl-3-isothioazoloneOctyl-3(2H)-isothiazolone

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 2; Acute Tox. 3; Acute Tox. 3; Skin Corr. 1; Eye Dam. 1; Skin Sens. 1A; Aquatic Acute 1; Aquatic Chronic 1H330; H311; H301; H314; H318; H317; H400; H410GHS06; GHS05; GHS09Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records
PreservativeBiocideAntioxidant

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 34 records
ListKeywordSource
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
SCIL (9/2019)USEPASafer Chemical Ingredients List
Europe; nondetect; Other direct contact consumer goodsDanish Environmental Protection AgencyDanish EPA
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
active_ingredient; Europe; PesticidesEuropean CommissionCPCat
active_ingredient; AustraliaAustralian Pesticides and Veterinary Medicines AuthorityCPCat
Pesticides; residueFDAUnited States Food and Drug Administration (FDA)
Pesticides; residueFDAUnited States Food and Drug Administration (FDA)
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat
active_ingredient; PesticidesMN Department of Agriculture Pesticide Sales DatabaseCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 77 studies
ValueUnitEndpointRouteSpeciesSource
14.525441368998uMAC50--NTP_ICE_endocrine
12.33017214uMACC--NTP_ICE_endocrine
12.72uL/min/10^6 cellsClint-HumanNTP_ICE_adme_parameters
1unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
2unitlessEPA ClassificationInhalation-NTP_ICE_acute_inhalation
3unitlessEPA ClassificationInhalation-NTP_ICE_acute_inhalation
3unitlessEPA ClassificationOcularRabbitNTP_ICE_eye_irritation
4unitlessEPA ClassificationInhalation-NTP_ICE_acute_inhalation
1unitlessEPA classificationDermalRabbitNTP_ICE_skin_irritation
=2UnitlessEPA classificationoralRat (Female)NTP_ICE_acute_oral
3unitlessEPA classificationDermalRatNTP_ICE_acute_dermal
=3UnitlessEPA classificationoralRat (Female)NTP_ICE_acute_oral
=3UnitlessEPA classificationoralRat (Female)NTP_ICE_acute_oral
3unitlessEPA classificationDermalRabbitNTP_ICE_skin_irritation
4unitlessEPA classificationDermalRatNTP_ICE_acute_dermal
4LFS24GD0VUNIIFDA UNII substance identifier--openFDA substances
4LFS24GD0VUNIIFDA UNII substance identifier--openFDA substances
4LFS24GD0VUNIIFDA UNII substance identifier--openFDA substances
4LFS24GD0VUNIIFDA UNII substance identifier--openFDA substances
0.02822fractionFu-HumanNTP_ICE_adme_parameters
1unitlessGHS ClassificationDermalGuinea pigNTP_ICE_skin_sensitization
=3UnitlessGHS classificationoralRat (Female)NTP_ICE_acute_oral
5unitlessGHS classificationDermalRatNTP_ICE_acute_dermal
=5UnitlessGHS classificationoralRat (Female)NTP_ICE_acute_oral
=5UnitlessGHS classificationoralRat (Female)NTP_ICE_acute_oral
0.38mg/LLC50Inhalation-NTP_ICE_acute_inhalation
range0.51mg/LLC50Inhalation-NTP_ICE_acute_inhalation
>2.07mg/LLC50Inhalation-NTP_ICE_acute_inhalation
=97mg/kg bwLD50oralRat (Female)NTP_ICE_acute_oral
=550mg/kg bwLD50oralRatNTP_ICE_acute_oral
>2000mg/kgLD50DermalRatNTP_ICE_acute_dermal
>2000mg/kg bwLD50oralRat (Female)NTP_ICE_acute_oral
=3129mg/kg bwLD50oralRat (Female)NTP_ICE_acute_oral
>5000mg/kgLD50DermalRatNTP_ICE_acute_dermal
=0.0365mg/kg bw/dayLELinhalationRatToxValDB_ToxRefDB
=0.0365mg/kg bw/dayLELinhalationrat (sprague dawley; Sprague Dawley (CD))ToxRefDB_ToxRefDB_v3_pod.csv
=30mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=30mg/kg bw/dayLELoralratToxRefDB_ToxRefDB_v3_pod.csv
=80mg/kg bw/dayLELoralRabbitToxValDB_ToxRefDB
=80mg/kg bw/dayLELoralrabbit (new zealand white; New Zealand White)ToxRefDB_ToxRefDB_v3_pod.csv
=96mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=96mg/kg bw/dayLELoralrat (wistar; Wistar (BR))ToxRefDB_ToxRefDB_v3_pod.csv
=107mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=107mg/kg bw/dayLELoralrat (wistar; Wistar (BR))ToxRefDB_ToxRefDB_v3_pod.csv
=111mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=111mg/kg bw/dayLELoralrat (wistar; Wistar (BR))ToxRefDB_ToxRefDB_v3_pod.csv
=120mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=120mg/kg bw/dayLELoralrat (wistar; Wistar (BR))ToxRefDB_ToxRefDB_v3_pod.csv
80mg/kg bw/dayLOELOralRabbitNTP_ICE_dart
80mg/kg bw/dayLOELOralRabbitNTP_ICE_dart

Showing 50 of 77 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registeredocthilinone (ISO); 2-octyl-2H-isothiazol-3-one247-761-7ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Preservatives
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1562104
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
4
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for Octhilinone?

Octhilinone (CAS 26530-20-1) is classified under EU CLP Annex VI as Acute Tox. 2; Acute Tox. 3; Acute Tox. 3; Skin Corr. 1; Eye Dam. 1; Skin Sens. 1A; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H330; H311; H301; H314; H318; H317; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Octhilinone?

Octhilinone has 77 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.

What regulatory lists include Octhilinone?

Octhilinone appears on 6 regulatory/inventory lists including active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, SCIL (9/2019), and 3 more. Source: EPA CPDat.

Is Octhilinone used in cosmetics?

Yes, Octhilinone is also indexed as a cosmetic ingredient under the name OCTYLISOTHIAZOLINONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Octhilinone come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does Octhilinone have different safety status in cosmetics vs industrial chemicals?

Octhilinone is classified GHS Danger (H330, H311, H301, H314, H318, H317, H400, H410) in the chemicals database but is allowed in EU cosmetics.

Is Octhilinone used outside industrial chemicals?

Octhilinone also appears in cosmetics, pharmaceutical databases.