Is OCTENE safe in cosmetics?
OCTENE has a safety rating of "GOOD" in our database. EU status: permitted. 1 toxicological study endpoint(s) are available in our database.
OCTENE
Also known as: Caprylene, alpha-Octylene, 1-n-Octene, Dialen 8, Gulftene 8 (+10 more)
OCTENE (CAS 111-66-0) is a cosmetic cosmetic ingredient functioning as Solvent. Reported NOAEL =1000 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 111-66-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
OCTENE is classified GHS Danger (H225, H304, H315, H411, H332, H336, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
IUPAC Name
oct-1-ene
InChIKey
KWKAKUADMBZCLK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
1 study endpoint found for OCTENE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. Exposure at high levels could cause lowering of consciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
0934
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Octenes may be more irritant to mucous membranes, skin, and eyes than the lower homologues. /Octenes/
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
2191
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
1-OCTENE | 2014 | No safety concern at current levels of intake when used as a flavouring agent | TRS 990-JECFA 79/62 | FAS 70-JECFA 79/169
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for OCTENE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to OCTENE by CAS number or substance name.
Studies
16
Lowest NOAEL
101 mg/kg bw/day
Highest NOAEL
1010 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
Caprylene
alpha-Octylene
1-n-Octene
Dialen 8
Gulftene 8
Linealene 8
Octa-1,8-diene
n-1-Octene
n-octene-1
Oct-1-ene
UN 1993
EINECS 203-893-7
UNII-E5VK21B9RC
1-C8H16
1-caprylene
Chemical Function
Flavouring and nutrient
Fragrance
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
CEDI
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1376677
Frequently Asked Questions
Is OCTENE allowed in the EU?
OCTENE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does OCTENE do in cosmetics?
OCTENE functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 111-66-0.
What is the NOAEL for OCTENE?
The NOAEL (No Observed Adverse Effect Level) for OCTENE is =1000 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is OCTENE used outside cosmetics?
OCTENE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does OCTENE have different safety status in cosmetics vs industrial chemicals?
OCTENE is classified GHS Danger (H225, H304, H315, H411, H332, H336, H400, H410) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check OCTENE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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