NOAEL Studies
Cosmetic Ingredient
NONYL ALCOHOL NOAEL Studies
CAS: 143-08-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =3560 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2675; row=10109; data_type=In Vivo; mixture=Chemical; chemical_name=1-Nonanol; preferred_name=1-Nonanol; dtxsid=DTXSID6022008; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022008; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =3200 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2673; row=10110; data_type=In Vivo; mixture=Chemical; chemical_name=1-Nonanol; preferred_name=1-Nonanol; dtxsid=DTXSID6022008; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022008; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=1246; RecordID=ARPathway2016_850; DatasetName=ARPathway2016; DTXSID=DTXSID6022008; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022008 |
NTP_ICE_skin_irritation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | TER | 1.5 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=4172; Record_ID=skin_irritation_invitro_2570; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6022008; Assay=TER Corrosion; Endpoint=TER; Response=1.5; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022008 |
| NTP_ICE_skin_irritation | TER | 2.5 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=4176; Record_ID=skin_irritation_invitro_2569; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID6022008; Assay=TER Corrosion; Endpoint=TER; Response=2.5; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022008 |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5494; Record_ID=skin_sensitization_invivo_1267; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6022008; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90068-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022008 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 1296 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5489; Record_ID=skin_sensitization_invivo_1267; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6022008; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1296; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90068-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022008 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5448; Record_ID=skin_sensitization_invivo_1267; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6022008; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1972: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90068-0; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6022008 |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =47201.2 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=DOE Protective Action Criteria:15517954:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b29c12fb17c6f003e9efa1c1f83d5227 |
ToxValDB_ECHA_IUCLID 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | =3000 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2065/7/3/2?documentUUID=d1db5e50-d408-47ff-84e4-ca18114e3f21; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID:15812251:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ab6ecb886ef3bdc774911b25fdc2db8f |
| ToxValDB_ECHA_IUCLID | NOAEC | =150 | mg/m3 | Rat | inhalation | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d18ae4b0a7c65d22f097; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13265/7/9/3?documentUUID=171c170e-088c-4954-9f1c-ae8663447f79; YEAR=1963; ORIGINAL_YEAR=1963; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820681_15821416_15821508_15821765:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a11b411ea4238a4a6c014fbf42458ff8 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1440 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc672; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/2065/7/9/3?documentUUID=d1db5e50-d408-47ff-84e4-ca18114e3f21; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID:15823846:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7af12e1bbbca5d7a57cf0345ccb46148 |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =118 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633822_15633823:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5e37a40b068ddf45d8d1463fb53747c1 |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =176 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15633822_15633823:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_42a15a7739e975aa98bbbc343baf7777 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | NGK73Q6XMC | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NGK73Q6XMC"} |
| openFDA substances | FDA UNII substance identifier | NGK73Q6XMC | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NGK73Q6XMC"} |
| openFDA substances | FDA UNII substance identifier | NGK73Q6XMC | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NGK73Q6XMC"} |
| openFDA substances | FDA UNII substance identifier | NGK73Q6XMC | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"NGK73Q6XMC"} |