Is Nonapeptide-1 safe in cosmetics?
Nonapeptide-1 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Nonapeptide-1
INCI: NONAPEPTIDE-1
Nonapeptide-1 (CAS 15858-45-2) is a cosmetic active ingredient functioning as Peptide / Anti-aging active. EU Regulation 1223/2009 status: permitted, max 2.0%. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 15858-45-2 →
Auto-generated CPSR Part A draft with source citations
Function
Peptide / Anti-aging active
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
EU Max Conc.
2.0%
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Nonapeptide-1.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
5 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "brightening, dark-spot-reduction", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "10-20", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, In…
anti_pollution
{"cas_number": "223749-135-2", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhib…
peptide
{"cas_number": "158563-45-2", "trade_name": "Melanostatine-5 / Luminescence", "peptide_sequence_amino_acids": "Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly", "peptide_length_residues": "10", "molecular_weight_daltons": "1206.3", "peptide_class": "enzyme_inhibitor", "mechanism_of_action": "Inhibits alpha-MSH, reduces tyrosinase activity and melanin synthesis", "target_protein_or_receptor": "MC1R antagon…
self_tanning
{"cas_number": "158563-45-2", "ingredient_class": "color_adjuster", "tanning_mechanism": "melanin_stimulation", "color_development_onset_hours": "72.0", "full_color_development_hours": "240", "color_duration_days": "14", "color_depth": "light", "undertone": "natural", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_release…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "5", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv": …
Expert Verdict
Expert safety assessment and concern-level summary for Nonapeptide-1.
Frequently Asked Questions
Is Nonapeptide-1 allowed in the EU?
Nonapeptide-1 EU regulatory status: permitted. Maximum allowed concentration: 2.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does Nonapeptide-1 do in cosmetics?
Nonapeptide-1 functions as: Peptide / Anti-aging active. It is classified as a Active Ingredient in our database. CAS number: 15858-45-2.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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