NOAEL Studies
Cosmetic Ingredient
NONANAL NOAEL Studies
CAS: 124-19-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
WHO/JECFA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | ADI | range:0-0.10.1 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jeceval_jec_1719; title=JECFA Evaluations-NONANAL-; path=mirror/documents/jecfa/jeceval/jec_1719.htm; row_hash=d689e3810154e289; raw_unit=mg/kg bw; context=THE 1984 GROUP ADI OF 0-0.1 mg/kg bw FOR OCTANAL AND NONANAL, SINGLY OR IN COMBINATION, WAS MAINTAINED AT THE FORTY-NINTH MEETING (1997). |
NTP ICE acute oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | LD50 | >5000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_1908; row=15418; data_type=In Vivo; mixture=Chemical; chemical_name=Nonanal; preferred_name=Nonanal; dtxsid=DTXSID9021639; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021639; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021639; source_file=acute_oral.xlsx |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=12370; RecordID=ARPathway2016_734; DatasetName=ARPathway2016; DTXSID=DTXSID9021639; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021639; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021639 |
NTP ICE skin sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4603; Record_ID=skin_sensitization_invivo_1106; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021639; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90074-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021639; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021639 |
| NTP ICE skin sensitization | Induction dose per skin area | 648 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4601; Record_ID=skin_sensitization_invivo_1106; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021639; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=648; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90074-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021639; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021639 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4607; Record_ID=skin_sensitization_invivo_1106; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID9021639; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1971: report to RIFM|Opdyke 1973; Not available; 10.1016/0015-6264(73)90074-6; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021639; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021639 |
ECHA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =1500 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b6206; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5471/7/9/2?documentUUID=8903ca86-bc3d-4f50-b698-e6335608d97a; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=P0: clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855318_15855597_15856158_15856384:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ec6a542e26ae902b27911c7855f8eb06 |
| ECHA | NOAEL | =200 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b6206; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5471/7/9/2?documentUUID=8903ca86-bc3d-4f50-b698-e6335608d97a; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=P0: clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855318_15855597_15856158_15856384:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8708368a9f1bf340f1cc0b763418a11f |
| ECHA | NOAEL | =300 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa7ee4b0a7c65d1b620c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5471/7/9/2?documentUUID=8903ca86-bc3d-4f50-b698-e6335608d97a; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=P0: clinical signs; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855318_15855597_15856158_15856384:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_493caf0839d916ef2ac8e66965574298 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =24.9 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15633818:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0bcf61cff1c5b55d26abb21edcf1855f |
ToxValDB HPVIS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HPVIS | NOAEL | =500 | mg/kg bw/day | Rabbit | dermal | short-term; 2 weeks | short-term | LONG_REF=Auletta C. (1981) A 28-day toxicity study in rabbits. Project No.6510-80. Unpublished report to FFHPVC.; TITLE=A 28-day toxicity study in rabbits; AUTHOR=Auletta, C. S; QUALITY=2; EXTERNAL_SOURCE_ID=63920; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS:15639463:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_42637e799d66d891669646b6d963a9b1 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 2L2WBY9K6T | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2L2WBY9K6T"} |
| openFDA substances | FDA UNII substance identifier | 2L2WBY9K6T | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2L2WBY9K6T"} |
| openFDA substances | FDA UNII substance identifier | 2L2WBY9K6T | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2L2WBY9K6T"} |
| openFDA substances | FDA UNII substance identifier | 2L2WBY9K6T | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2L2WBY9K6T"} |