Is NITROFURAZONE safe in cosmetics?
NITROFURAZONE has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted.
Good
Cosmetic Ingredient
NITROFURAZONE
Also known as: 5-Nitro-2-furaldehyde semicarbazone, Hydrazinecarboxamide, 2-[(5-nitro-2-furanyl)methylene]-, 2-Furancarboxaldehyde, 5-nitro-,semicarbazone, Actin-N, Becafurazone (+15 more)
NITROFURAZONE (CAS 59-87-0) is a cosmetic cosmetic ingredient functioning as Antimicrobial. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 59-87-0 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
[(E)-(5-nitrofuran-2-yl)methylideneamino]urea
InChIKey
IAIWVQXQOWNYOU-FPYGCLRLSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Restricted — FDA has withdrawn approval for nitrofuran drugs in food-producing animals; not accepted for cosmetic use due to safety concerns
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
50
Evaluation Year
1989
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
124 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [31] Kligman AM (1966): https://doi.org/10.1038/jid.1966.159
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 124.14 | - | - |
| HMT | - | 0 | 620.69 | - | - |
| HMT | - | 0 | 6206.9 | - | - |
| HMT | - | 0 | 15517.24 | - | - |
| HMT | - | 0 | 31034.48 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
3, not classifiable as to its carcinogenicity to humans. (L135)
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
Nitrofural (Nitrofurazone) | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 50: (1990) Pharmaceutical Drugs
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
Nitrofurazone | TR-337: Toxicology and Carcinogenesis Studies of Nitrofurazone (CASRN 59-87-0) in F344/N Rats and B6C3F1 Mice (Feed Studies) (1988 ) | 07/14/87 | Equivocal Evidence | Clear Evidence | No Evidence | Clear Evidence | Under the conditions of these 2-year feed studies, there was equivocal evidence of carcinogenic activity of nitrofurazone for male F344/N rats as shown by the o
Source: NTP Technical Reports
Evidence for Carcinogenicity
Evaluation: There is inadequate evidence for the carcinogenicity of nitrofural in humans. There is limited evidence for the carcinogenicity of nitrofural in experimental animals. Overall evaluation: Nitrofural is not classifiable as to its carcinogenicity to humans (Group 3).
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (1)
JECFA Evaluation
NITROFURAL | 1993 | NO ADI ALLOCATED | The Committee concluded that it could not establish an ADI for nitrofural because no-effect levels had not been established for the tumorigenic effects. Although a no-effect level (15 mg/kg bw/day) had been established in rats for testicular hypoplasia in a 13-week study, a slightly lower dose (11 mg/kg bw/day) resulted in a high incidence of testicular degen
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Regulatory List Membership (1)
California Proposition 65 (OEHHA)
Expert Verdict
Expert safety assessment and concern-level summary for NITROFURAZONE.
Regulatory Flags
cosing-sourced
eu-permitted
preservative
needs-enrichment
prop65
jecfa_concern
Known Synonyms
5-Nitro-2-furaldehyde semicarbazone
Hydrazinecarboxamide, 2-[(5-nitro-2-furanyl)methylene]-
2-Furancarboxaldehyde, 5-nitro-,semicarbazone
Actin-N
Becafurazone
Biofuracina
Biofurea
BRN 0086403
Cocafurin
Dermofural
Dynazone
EINECS 200-443-1
Eldezol
Eldezol F-6
Fedacin
Flavazone
Fracine
Furacillin
Furacin-E
Furacin-HC
Chemical Function
Biocide
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
active_ingredient; Australia
OEHHA Proposition 65 (3/2019)
OEHHA Proposition 65 (1/2023)
Frequently Asked Questions
Is NITROFURAZONE allowed in the EU?
NITROFURAZONE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NITROFURAZONE do in cosmetics?
NITROFURAZONE functions as: Antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 59-87-0.
Is NITROFURAZONE used outside cosmetics?
NITROFURAZONE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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