Is Neopentyl Glycol Dimethacrylate safe in cosmetics?
Neopentyl Glycol Dimethacrylate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Neopentyl Glycol Dimethacrylate
Also known as: Acrylic acid, 2,2-dimethyl-1,3-propanediol diester, Dimethylolpropane diacrylate, 2,2-Dimethylpropane diacrylate, 2,2-Dimethylpropane-1,3-diol diacrylate, EINECS 218-741-5 (+5 more)
INCI: NEOPENTYL GLYCOL DIMETHACRYLATE
Neopentyl Glycol Dimethacrylate (CAS 2223-82-7) is a cosmetic cosmetic ingredient functioning as Nail enhancement polymer, film former. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 2223-82-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Neopentyl Glycol Dimethacrylate is classified GHS Danger (H310, H311, H315, H317, H319) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Nail enhancement polymer, film former
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2,2-dimethyl-3-prop-2-enoyloxypropyl) prop-2-enoate
InChIKey
MXFQRSUWYYSPOC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted - CIR reviewed; safe when skin contact avoided
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Neopentyl Glycol Dimethacrylate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation and through the skin.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Acute Toxicity
Hazard Class and Category
Acute Tox. 3 *; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1
Hazard Statements
- H311 Toxic in contact with skin
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H317 May cause an allergic skin reaction
Specific Concentration Limits / M-factors
*
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1286
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
The lower-molecular-wt esters of acrylic acids are irritants to skin, eyes and mucous membranes. /Acrylic acid esters/
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Monomers
Expert Verdict
Expert safety assessment and concern-level summary for Neopentyl Glycol Dimethacrylate.
Known Synonyms
Acrylic acid, 2,2-dimethyl-1,3-propanediol diester
Dimethylolpropane diacrylate
2,2-Dimethylpropane diacrylate
2,2-Dimethylpropane-1,3-diol diacrylate
EINECS 218-741-5
Neopentyl glycol diacrylate
NSC 97407
1,3-Propanediol, 2,2-dimethyl-, diacrylate
Viscoat 247
UNII-0OHU17DNNU
Chemical Function
Monomers
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Neopentyl Glycol Dimethacrylate allowed in the EU?
Neopentyl Glycol Dimethacrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Neopentyl Glycol Dimethacrylate do in cosmetics?
Neopentyl Glycol Dimethacrylate functions as: Nail enhancement polymer, film former. It is classified as a cosmetic ingredient in our database. CAS number: 2223-82-7.
Is Neopentyl Glycol Dimethacrylate used outside cosmetics?
Neopentyl Glycol Dimethacrylate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Neopentyl Glycol Dimethacrylate have different safety status in cosmetics vs industrial chemicals?
Neopentyl Glycol Dimethacrylate is classified GHS Danger (H310, H311, H315, H317, H319) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Neopentyl Glycol Dimethacrylate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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