Is Neomycin safe in cosmetics?
Neomycin has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted.
Neomycin
INCI: NEOMYCIN SULFATE
Neomycin (CAS 1404-04-2 (base); 1405-10-3 (sulfate salt)) is a cosmetic cosmetic ingredient functioning as Antimicrobial. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 1404-04-2 (base); 1405-10-3 (sulfate salt) →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial
Safety Rating
POOR
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Regulated as an OTC drug (antibiotic) by FDA. Any product containing neomycin is classified as a drug, not a cosmetic.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Neomycin.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Neomycin based on clinical patch test studies and IFRA standards.
Sensitization Rate
moderate
Allergen Class
other
EU Allergen Listed
no
Patch Test Positive Rate
3.5%
Cross-reactivity Group
aminoglycoside-group
Reaction Type
contact-dermatitis
Source: NACDG
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "other", "cross_reactivity_group": "aminoglycoside-group", "patch_test_frequency_pct": "3.5", "sensitization_rate": "moderate", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "NACDG"}
Expert Verdict
Expert safety assessment and concern-level summary for Neomycin.
Regulatory Flags
potential-allergen
Frequently Asked Questions
Is Neomycin allowed in the EU?
Neomycin EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Neomycin do in cosmetics?
Neomycin functions as: Antimicrobial. It is classified as a cosmetic ingredient in our database. CAS number: 1404-04-2 (base); 1405-10-3 (sulfate salt).
Compliance Tools
Check Neomycin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acrylates/Vinyl Neodecanoate Crosspolymer
Excellent
Same category
Emulsion stabilising, film forming
Adipic Acid
Excellent
Same category
Buffering
Aluminum Magnesium Oxide
Excellent
Same category
Absorbent, bulking agent, opacifying ...
Ammonium VA/Acrylates Copolymer
Excellent
Same category
Antistatic, binding, film forming, ha...
Ammonium VA/Crotonic Acid Copolymer
Excellent
Same category
Antistatic, film forming, hair fixing...
Aphanothece Sacrum Polysaccharide
Excellent
Same category
Absorbent, emulsion stabilising, film...
1,2,4-Benzenetriacetate
Poor
Similar safety
Hair dye precursor (triacetyl ester o...
1,2,4-Trihydroxybenzene
Poor
Similar safety
Hair colorant (auto-oxidative dye)
1,4-Butanediol
Poor
Similar safety
Solvent, humectant, viscosity control...
1-Nitropropane
Poor
Similar safety
None in cosmetics - industrial solven...
2,3-Epoxypropyl Cocodimonium Chloride
Poor
Similar safety
Antistatic / hair conditioning agent ...
2,3-Epoxypropyl Lauryldimonium Chloride
Poor
Similar safety
Antistatic / hair conditioning agent ...
NEOCHEIROPTERIS ENSATA EXTRACT
Good
Browse nearby
Antioxidant
NEOCHLORIS OLEOABUNDANS EXTRACT
Good
Browse nearby
Skin Conditioning
NEOFINETIA FALCATA CALLUS CULTURE EXTRACT
Good
Browse nearby
Skin Conditioning
Is Neomycin in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Neomycin in your formulation.