Is N-HYDROXYSUCCINIMIDE safe in cosmetics?
N-HYDROXYSUCCINIMIDE has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed.
Good
Cosmetic Ingredient
N-HYDROXYSUCCINIMIDE
Also known as: EINECS 228-001-3, UNII-MJE3791M4T
N-HYDROXYSUCCINIMIDE (CAS 6066-82-6) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 6066-82-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1-hydroxypyrrolidine-2,5-dione
InChIKey
NQTADLQHYWFPDB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
Allowed under general cosmetic provisions; no specific prohibition.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for N-HYDROXYSUCCINIMIDE.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
Known Synonyms
EINECS 228-001-3
UNII-MJE3791M4T
Chemical Function
Softener and conditioner
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL403753
Frequently Asked Questions
Is N-HYDROXYSUCCINIMIDE allowed in the EU?
N-HYDROXYSUCCINIMIDE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does N-HYDROXYSUCCINIMIDE do in cosmetics?
N-HYDROXYSUCCINIMIDE functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 6066-82-6.
Is N-HYDROXYSUCCINIMIDE used outside cosmetics?
N-HYDROXYSUCCINIMIDE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check N-HYDROXYSUCCINIMIDE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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