Is MYRCENE safe in cosmetics?
MYRCENE has a safety rating of "GOOD" in our database. EU status: permitted. US status: prohibited.
Good
Cosmetic Ingredient
MYRCENE
Also known as: beta-Myrcene, 1,6-Octadiene, 7-methyl-3-methylene-, 4-01-00-01108, BRN 1719990, EINECS 204-622-5 (+13 more)
MYRCENE (CAS 123-35-3) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 53 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 123-35-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
MYRCENE is classified GHS Danger (H226, H304, H315, H319, H400, H412, H351, H361) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Chemistry & Identifiers
IUPAC Name
7-methyl-3-methylideneocta-1,6-diene
InChIKey
UAHWPYUMFXYFJY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
| Allowed — FEMA GRAS No. 2762 for flavor use; not prohibited in cosmetics scentspiracy | | **Safety Concerns** | Oxidation products may cause skin sensitization — stabilization with antioxidants is recommended; classified as flammable under REACH; auto-polymerizes under air/light exposure scents...
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for MYRCENE across SCCS product categories, with measured dermal absorption where available.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2B
Volume
119
Evaluation Year
2017
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
β-Myrcene | Group 2B: Possibly carcinogenic to humans | Volume 119: (2019) Some Chemicals That Cause Tumours of the Urinary Tract in Rodents
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
β-Myrcene | TR-557: Toxicology and Carcinogenesis Studies of beta-Myrcene (CASRN 123-35-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (2010 ) | 02/25/09 | Clear Evidence | Equivocal Evidence | Clear Evidence | Equivocal Evidence | Under the conditions of these 2-year gavage studies, there was clear evidence of carcinogenic activity of β-myrcene in male F344/N rats based on inc
Source: NTP Technical Reports
Skin Eye Respiratory Irritation
A moderate skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (3)
JECFA Number
1327
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
7-METHYL-3-METHYLENEOCTA-1,6-DIENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
MYRCENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
California Proposition 65 (OEHHA)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for MYRCENE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
prop65
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
beta-Myrcene
1,6-Octadiene, 7-methyl-3-methylene-
4-01-00-01108
BRN 1719990
EINECS 204-622-5
FEMA No. 2762
UNII-3M39CZS25B
3-Methylene-7-methyl-1, 6-octadiene
7-Methyl-3-methylene-1,6-octadiene (beta -myrcene)
7-Methyl-3-methylene-1,6-octadiene (myrcene)
7-Methyl-3-methylene-octa-1,6-diene
7-Methyl-3-methyleneoctadiene-(1,6)
7-Methyl-3-methylideneocta-1,6-diene
B-Geraniolene
FEMA 2762
b-Myrcene
beta -mircene
beta -myrcene
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Cleaning products and household care - air freshener; Europe
air; Cleaning products and household care - air freshener; detected; emissions; Europe
detected; Europe; Personal care - liniment
air; detected; emissions; Europe; Vehicle - car interior
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - sexual wellness
OEHHA Proposition 65 (3/2019)
Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe
Europe; Personal care - liniment
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
OEHHA Proposition 65 (1/2023)
air; Cleaning products and household care - air freshener; detected; emissions; Europe
IFRA Transparency
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
MYRCENE
ChEMBL ID
CHEMBL455491
Max Phase
1
Frequently Asked Questions
Is MYRCENE allowed in the EU?
MYRCENE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does MYRCENE do in cosmetics?
MYRCENE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 123-35-3.
Is MYRCENE used outside cosmetics?
MYRCENE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does MYRCENE have different safety status in cosmetics vs industrial chemicals?
MYRCENE is classified GHS Danger (H226, H304, H315, H319, H400, H412, H351, H361) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check MYRCENE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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Chemical family
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