Is Muscone safe in cosmetics?
Muscone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Muscone
Also known as: Cyclopentadecanone, 3-methyl-, (+/-)-Muscone, Muskone, dl-Muscone, EINECS 208-795-8 (+7 more)
INCI: MUSCONE
Muscone (CAS 541-91-3) is a cosmetic cosmetic ingredient functioning as Perfuming (macrocyclic musk base note). NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 541-91-3 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming (macrocyclic musk base note)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-methylcyclopentadecan-1-one
InChIKey
ALHUZKCOMYUFRB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS 3434 as flavoring agent; no substance-specific FDA restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Muscone.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Muscone across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 20250 | - | - |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: fragrance
Receptor targets: ERα (weak)
LOEC: 10 µM
EU status: allowed
weak agonist
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
fragrance
{"cas_number": "541-91-3", "ingredient_class": "synthetic_musk", "chemical_class": "macrocyclic", "odor_family": "musk", "odor_description": "True musk, warm, animalic, rich", "odor_strength": "strong", "odor_tenacity_hours": "336.0", "top_note": "no", "heart_note": "no", "base_note": "yes", "blending_factor_1_10": "9.0", "threshold_of_detection_ppb": "5.0", "molecular_weight_Da": "238.41", "boili…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1402
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-METHYL-1-CYCLOPENTADECANONE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/86 | FAS 54-JECFA 63/385
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
METHYLEXALTONE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/86 | FAS 54-JECFA 63/385
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Muscone.
Regulatory Flags
Environmental
Allergen
ifra_fragrance
fda_food_additive
Known Synonyms
Cyclopentadecanone, 3-methyl-
(+/-)-Muscone
Muskone
dl-Muscone
EINECS 208-795-8
FEMA No. 3434
3-Methylcyclopentadecanone
3-Methyl-1-cyclopentadecanone
5-Methyl-1-cyclopentadecanone
Methylexaltone
Moschus ketone
UNII-5JO79R7S9R
Chemical Function
Deodorizer
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Muscone allowed in the EU?
Muscone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Muscone do in cosmetics?
Muscone functions as: Perfuming (macrocyclic musk base note). It is classified as a cosmetic ingredient in our database. CAS number: 541-91-3.
Is Muscone used outside cosmetics?
Muscone also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Muscone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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