Is CYCLOTRISILOXANE safe in cosmetics?
CYCLOTRISILOXANE has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
CYCLOTRISILOXANE
Also known as: Benzenemethanol, α-(1-aminoethyl)-, hydrochloride
CYCLOTRISILOXANE (CAS 541-05-9) is a cosmetic cosmetic ingredient functioning as Hair Conditioning, Skin Conditioning, Skin Conditioning - Emollient, Solvent. NOAEL 25 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 541-05-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
CYCLOTRISILOXANE is classified GHS Danger (H228) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair Conditioning, Skin Conditioning, Skin Conditioning - Emollient, Solvent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2,2,4,4,6,6-hexamethyl-1,3,5,2,4,6-trioxatrisilinane
InChIKey
HTDJPCNNEPUOOQ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for CYCLOTRISILOXANE across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Solvent
Expert Verdict
Expert safety assessment and concern-level summary for CYCLOTRISILOXANE.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
hair-conditioning
emollient
needs-enrichment
Known Synonyms
Benzenemethanol, α-(1-aminoethyl)-, hydrochloride
Chemical Function
Solvent
Softener and conditioner
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3182063
Frequently Asked Questions
Is CYCLOTRISILOXANE allowed in the EU?
CYCLOTRISILOXANE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CYCLOTRISILOXANE do in cosmetics?
CYCLOTRISILOXANE functions as: Hair Conditioning, Skin Conditioning, Skin Conditioning - Emollient, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 541-05-9.
Is CYCLOTRISILOXANE used outside cosmetics?
CYCLOTRISILOXANE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does CYCLOTRISILOXANE have different safety status in cosmetics vs industrial chemicals?
CYCLOTRISILOXANE is classified GHS Danger (H228) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check CYCLOTRISILOXANE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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