Is Morus Alba Root Extract safe in cosmetics?
Morus Alba Root Extract has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Morus Alba Root Extract
Also known as: Myristic acid, 4-02-00-01126, C14 fatty acid, BRN 0508624, EINECS 208-875-2 (+15 more)
INCI: MORUS ALBA ROOT EXTRACT
Morus Alba Root Extract (CAS 544-63-8) is a cosmetic active ingredient functioning as Skin brightening, antioxidant, skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 544-63-8 →
Auto-generated CPSR Part A draft with source citations
Function
Skin brightening, antioxidant, skin conditioning
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA pre-market approval required for cosmetic use. No CIR assessment for mulberroside F specifically. No GRAS listing relevant to topical use. MoCRA safety substantiation required. Not subject to hydroquinone OTC drug concerns (unlike arbutin).
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Morus Alba Root Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
7 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOEL | =5 % w/v | Rat | dermal | acute | ECOTOX |
| NOEL | =5 % w/v | Rat | dermal | short-term | ECOTOX |
| NOEL | =5 % w/v | Rat | dermal | short-term | ECOTOX |
| NOEL | =5 % w/v | Rat | dermal | acute | ECOTOX |
| NOEL | =0.9 mM | European Rabbit | environmental | short-term | ECOTOX |
| NOEL | =0.09 mM | European Rabbit | environmental | short-term | ECOTOX |
| LD50 | >10000 mg/kg | Rat | oral | - | ChemIDplus |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "brightening, dark-spot-reduction", "mechanism_of_action": "Mulberroside, arbutin", "target_skin_layer": "epidermis", "collagen_stimulation": "No", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "Phytotherapy Research, JOCD", "impr…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Cleaning agent
Emulsifier
Flavouring and nutrient
Fragrance
Lubricating agent
No specific technical function
Opacifer
Plasticizer
Surfactant (surface active agent)
Regulatory List Membership (5)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Morus Alba Root Extract.
Regulatory Flags
eu-unrestricted
no-sccs-opinion
skin-brightening
tyrosinase-inhibitor
mulberroside-f
oxyresveratrol
arbutin-alternative
no-hydroquinone-release
anti-hyperpigmentation
k-beauty
in-vitro-evidence
eu_children_restricted
epa_safer_alternative
ifra_fragrance
fda_food_additive
Known Synonyms
Myristic acid
4-02-00-01126
C14 fatty acid
BRN 0508624
EINECS 208-875-2
FEMA No. 2764
Hydrofol acid 1495
UNII-0I3V7S25AW
1-Tridecanecarboxylate
1-tetradecanecarboxylic acid
14
14:0
14:00
C14
CH3-[CH2]12-COOH
Crodacid
Myristate
Myristic acid pure
Myristoate
Myristoic acid
Chemical Function
Emulsifier
Fragrance
Cleaning agent
No specific technical function
Opacifer
Surfactant (surface active agent)
Flavouring and nutrient
Regulatory Lists
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
active_ingredient; Europe; Pesticides
children; Europe; Personal care
Australia; Food and drug - smoking-related products
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
consumer_product
inert_ingredient; Pesticides
Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; Europe
air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe
detected; Europe; Other direct contact consumer goods
detected; Europe; Other direct contact consumer goods
Europe
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
MYRISTIC ACID
ChEMBL ID
CHEMBL111077
Max Phase
-1
Frequently Asked Questions
Is Morus Alba Root Extract allowed in the EU?
Morus Alba Root Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Morus Alba Root Extract do in cosmetics?
Morus Alba Root Extract functions as: Skin brightening, antioxidant, skin conditioning. It is classified as a Active Ingredient in our database. CAS number: 544-63-8.
Is Morus Alba Root Extract used outside cosmetics?
Morus Alba Root Extract also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Morus Alba Root Extract compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acetyl Tetrapeptide-5
Excellent
Same category
Anti-edema peptide for periorbital ar...
Activated Charcoal
Excellent
Same category
Adsorbent; skin cleanser; pore-cleans...
Adenosine
Excellent
Same category
Skin-conditioning agent, anti-aging, ...
Allantoin
Excellent
Same category
Skin conditioner, keratolytic, anti-i...
Alpha-Glucan Oligosaccharide
Excellent
Same category
prebiotic, skin-conditioning
Ascophyllum Nodosum Extract
Excellent
Same category
Skin Brightening, Tyrosinase Inhibito...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
Ammonium Oleate
Good
Chemical family
Surfactant – Emulsifying, Cleansing
Batyl Alcohol
Excellent
Chemical family
Emulsion stabilising, skin conditioni...
Dibutyl Sulphide
Poor
Chemical family
Masking agent (limited cosmetic relev...
Is Morus Alba Root Extract in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Morus Alba Root Extract in your formulation.